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• W1808995917 startingPage "5079" @default.
• W1808995917 abstract "Destruction of spiral ganglion neurons (SGNs) induced by injury and toxins is one of the major causes for hearing loss. Here we report that neurotrophin-4/5 (NT-4/5), a member of the nerve growth factor family, promoted survival of postnatal rat SGNs up to threefold in dissociated cell cultures. The survival-promoting potency of NT-4/5 was equivalent to that of BDNF and stronger than that of NT-3. In contrast, NGF showed no detectable effects. Immunohistochemistry, with TrkB and TrkA antisera, revealed that these neurons produced TrkB protein, the functional receptor for NT-4/5 and BDNF, but not TrkA protein, the high-affinity receptor for NGF. The survival-promoting activity of NT-4/5 was completely inhibited by TrkB-IgG fusion protein. These results suggest that NT-4/5 is a specific survival factor for SGNs. In addition, NT-4/5 protected the SGNs from neurotoxic effects of the anti-cancer drug, cisplatin. Thus, NT-4/5 may have therapeutic value in preventing hearing impairment caused by damage to primary auditory afferent neurons." @default.
• W1808995917 created "2016-06-24" @default.
• W1808995917 creator A5048246560 @default.
• W1808995917 creator A5081148554 @default.
• W1808995917 creator A5086877240 @default.
• W1808995917 date "1995-07-01" @default.
• W1808995917 modified "2023-09-25" @default.
• W1808995917 title "Neurotrophin-4/5 enhances survival of cultured spiral ganglion neurons and protects them from cisplatin neurotoxicity" @default.
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• W1808995917 doi "https://doi.org/10.1523/jneurosci.15-07-05079.1995" @default.
• W1808995917 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6577912" @default.
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