FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1809136002> ?p ?o ?g. }

• W1809136002 endingPage "4000" @default.
• W1809136002 startingPage "4000" @default.
• W1809136002 abstract "4000 Background: New clinical tools are needed to improve risk assessment and treatment decisions in stage II colon cancer. Four development studies [Surgery (Sx) alone: NSABP C-01/C-02 (n=270) and CCF study (n=765); Sx+5FU/LV: NSABP C-04 (n=308) and C-06 (n=508)] were performed to select the genes for prediction of recurrence and 5FU/LV benefit. To determine clinical utility of the prespecified assay, we performed a large, independent, prospectively designed, clinical validation study in stage II colon cancer pts from the QUASAR trial. Methods: Gene expression was quantitated by RT-PCR from 30 μm manually microdissected fixed paraffin-embedded primary colon cancer tissue. Recurrence-free interval (RFI), disease-free survival (DFS), and overall survival (OS) were analyzed using Cox regression. Results: Combined analysis of the four development studies (total n=1,851; 761 candidate genes) identified 48 genes significantly associated with recurrence risk and 66 genes predictive of 5FU/LV benefit. Multivariate analysis, in the context of stage, grade, nodes examined, and MSI status, yielded 18 genes (7 prognostic genes, 6 predictive genes, 5 reference genes) and separate prognostic recurrence score (RS) and predictive treatment score (TS) algorithms. In the QUASAR validation study, tumor blocks were collected for 68% of pts; 1,490 pts with blocks had stage II colon cancer and RT-PCR was successful in 1,436 eligible pts (711 Sx, 725 Sx+5FU/LV). Median FU=6.6 yrs. In the primary analysis of RFI in pts following Sx, the RS predicted recurrence risk (HR/25 units=1.58, 95% CI 1.15–2.15; p=0.004). The RS also predicted DFS (p=0.01) and OS (p=0.04). Recurrence risk increased monotonically with increasing RS. In multivariate analyses, RS retained prognostic significance (p=0.008) independent of mismatch repair (MMR), T stage, nodes examined, grade, and lymphovascular invasion. MMR deficiency (HR=0.31, 95% CI 0.15–0.63; p<0.001) and T4 stage (HR=1.94, 95% CI 1.35–2.79; p=0.005), together ∼25% of pts, also were independently prognostic. 5FU/LV benefit was significant (p<0.001). However, TS was not validated as a predictor of 5FU/LV benefit (interaction p=0.19). Conclusions: The colon cancer recurrence score is a validated, independent predictor of individualized recurrence risk for stage II colon cancer patients following surgery. [Table: see text]" @default.
• W1809136002 created "2016-06-24" @default.
• W1809136002 creator A5000005779 @default.
• W1809136002 creator A5006984522 @default.
• W1809136002 creator A5038426439 @default.
• W1809136002 creator A5048859997 @default.
• W1809136002 creator A5055013606 @default.
• W1809136002 creator A5056629892 @default.
• W1809136002 creator A5057152092 @default.
• W1809136002 creator A5057918523 @default.
• W1809136002 creator A5062302578 @default.
• W1809136002 creator A5076602563 @default.
• W1809136002 creator A5088120956 @default.
• W1809136002 date "2009-05-20" @default.
• W1809136002 modified "2023-10-15" @default.
• W1809136002 title "A quantitative multigene RT-PCR assay for prediction of recurrence in stage II colon cancer: Selection of the genes in four large studies and results of the independent, prospectively designed QUASAR validation study" @default.
• W1809136002 doi "https://doi.org/10.1200/jco.2009.27.15_suppl.4000" @default.
• W1809136002 hasPublicationYear "2009" @default.
• W1809136002 type Work @default.
• W1809136002 sameAs 1809136002 @default.
• W1809136002 citedByCount "75" @default.
• W1809136002 countsByYear W18091360022012 @default.
• W1809136002 countsByYear W18091360022013 @default.
• W1809136002 countsByYear W18091360022014 @default.
• W1809136002 countsByYear W18091360022015 @default.
• W1809136002 countsByYear W18091360022016 @default.
• W1809136002 countsByYear W18091360022017 @default.
• W1809136002 countsByYear W18091360022018 @default.
• W1809136002 countsByYear W18091360022019 @default.
• W1809136002 countsByYear W18091360022020 @default.
• W1809136002 countsByYear W18091360022021 @default.
• W1809136002 crossrefType "journal-article" @default.
• W1809136002 hasAuthorship W1809136002A5000005779 @default.
• W1809136002 hasAuthorship W1809136002A5006984522 @default.
• W1809136002 hasAuthorship W1809136002A5038426439 @default.
• W1809136002 hasAuthorship W1809136002A5048859997 @default.
• W1809136002 hasAuthorship W1809136002A5055013606 @default.
• W1809136002 hasAuthorship W1809136002A5056629892 @default.
• W1809136002 hasAuthorship W1809136002A5057152092 @default.
• W1809136002 hasAuthorship W1809136002A5057918523 @default.
• W1809136002 hasAuthorship W1809136002A5062302578 @default.
• W1809136002 hasAuthorship W1809136002A5076602563 @default.
• W1809136002 hasAuthorship W1809136002A5088120956 @default.
• W1809136002 hasConcept C121608353 @default.
• W1809136002 hasConcept C126322002 @default.
• W1809136002 hasConcept C143998085 @default.
• W1809136002 hasConcept C146357865 @default.
• W1809136002 hasConcept C151730666 @default.
• W1809136002 hasConcept C2779343474 @default.
• W1809136002 hasConcept C50382708 @default.
• W1809136002 hasConcept C526805850 @default.
• W1809136002 hasConcept C71924100 @default.
• W1809136002 hasConcept C86803240 @default.
• W1809136002 hasConcept C90924648 @default.
• W1809136002 hasConceptScore W1809136002C121608353 @default.
• W1809136002 hasConceptScore W1809136002C126322002 @default.
• W1809136002 hasConceptScore W1809136002C143998085 @default.
• W1809136002 hasConceptScore W1809136002C146357865 @default.
• W1809136002 hasConceptScore W1809136002C151730666 @default.
• W1809136002 hasConceptScore W1809136002C2779343474 @default.
• W1809136002 hasConceptScore W1809136002C50382708 @default.
• W1809136002 hasConceptScore W1809136002C526805850 @default.
• W1809136002 hasConceptScore W1809136002C71924100 @default.
• W1809136002 hasConceptScore W1809136002C86803240 @default.
• W1809136002 hasConceptScore W1809136002C90924648 @default.
• W1809136002 hasIssue "15_suppl" @default.
• W1809136002 hasLocation W18091360021 @default.
• W1809136002 hasOpenAccess W1809136002 @default.
• W1809136002 hasPrimaryLocation W18091360021 @default.
• W1809136002 hasRelatedWork W1964399992 @default.
• W1809136002 hasRelatedWork W2356105190 @default.
• W1809136002 hasRelatedWork W2392730113 @default.
• W1809136002 hasRelatedWork W2409949902 @default.
• W1809136002 hasRelatedWork W2542604898 @default.
• W1809136002 hasRelatedWork W3004259476 @default.
• W1809136002 hasRelatedWork W3005389614 @default.
• W1809136002 hasRelatedWork W3039284339 @default.
• W1809136002 hasRelatedWork W4224285874 @default.
• W1809136002 hasRelatedWork W4308471549 @default.
• W1809136002 hasVolume "27" @default.
• W1809136002 isParatext "false" @default.
• W1809136002 isRetracted "false" @default.
• W1809136002 magId "1809136002" @default.
• W1809136002 workType "article" @default.