FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1809295614> ?p ?o ?g. }

• W1809295614 endingPage "2496" @default.
• W1809295614 startingPage "2492" @default.
• W1809295614 abstract "Similar to other human and animal lentiviruses, equine infectious anemia virus (EIAV) is detectable in vivo in cells of the monocyte-macrophage lineage. Owing to their short-lived nature, horse peripheral blood macrophage cultures (HMC) are rarely used for in vitro propagation of EIAV, and equine dermal (ED) or kidney cell cultures, which can be repeatedly passed in vitro, are used in most studies. However, wild-type isolates of EIAV will not grow in these cell types without extensive adaptation, a process which may attenuate viral virulence. To better define the effect of host cell tropism on the virulence and pathogenesis of EIAV, we studied a field isolate of EIAV during in vitro adaptation to growth in an ED cell line. Interestingly, as the virus adapted to growth in ED cells, there was a corresponding decrease in infectivity for HMC, and the final ED-adapted isolate was more than 100-fold more infectious for ED cells than for HMC. In vivo studies indicated that the ED-adapted isolate was able to replicate in experimentally infected horses, although no clinical signs of EIA were observed. Thus, selection for in vitro replication on ED cells correlated with a loss of EIAV tropism for HMC in vitro and was associated with avirulence in vivo." @default.
• W1809295614 created "2016-06-24" @default.
• W1809295614 creator A5032220933 @default.
• W1809295614 creator A5054510818 @default.
• W1809295614 date "1989-06-01" @default.
• W1809295614 modified "2023-09-25" @default.
• W1809295614 title "Change in host cell tropism associated with in vitro replication of equine infectious anemia virus" @default.
• W1809295614 cites W1527352542 @default.
• W1809295614 cites W1547374706 @default.
• W1809295614 cites W1602075566 @default.
• W1809295614 cites W1609333127 @default.
• W1809295614 cites W1739576709 @default.
• W1809295614 cites W1926094917 @default.
• W1809295614 cites W1947695753 @default.
• W1809295614 cites W1950343951 @default.
• W1809295614 cites W1978039778 @default.
• W1809295614 cites W1999059818 @default.
• W1809295614 cites W2010340688 @default.
• W1809295614 cites W2011918985 @default.
• W1809295614 cites W2014074003 @default.
• W1809295614 cites W2015979176 @default.
• W1809295614 cites W2016780880 @default.
• W1809295614 cites W2025347724 @default.
• W1809295614 cites W2058256613 @default.
• W1809295614 cites W2065114401 @default.
• W1809295614 cites W2066121768 @default.
• W1809295614 cites W2066952037 @default.
• W1809295614 cites W2084938604 @default.
• W1809295614 cites W2087168358 @default.
• W1809295614 cites W2091847974 @default.
• W1809295614 cites W2114601677 @default.
• W1809295614 cites W2141881408 @default.
• W1809295614 cites W2142638152 @default.
• W1809295614 cites W2151862112 @default.
• W1809295614 cites W234388831 @default.
• W1809295614 cites W2411465149 @default.
• W1809295614 cites W2411590787 @default.
• W1809295614 cites W2412556918 @default.
• W1809295614 cites W2413796538 @default.
• W1809295614 cites W2474920158 @default.
• W1809295614 cites W323400900 @default.
• W1809295614 cites W2395770288 @default.
• W1809295614 cites W326671813 @default.
• W1809295614 doi "https://doi.org/10.1128/jvi.63.6.2492-2496.1989" @default.
• W1809295614 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/250709" @default.
• W1809295614 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2470916" @default.
• W1809295614 hasPublicationYear "1989" @default.
• W1809295614 type Work @default.
• W1809295614 sameAs 1809295614 @default.
• W1809295614 citedByCount "63" @default.
• W1809295614 countsByYear W18092956142013 @default.
• W1809295614 countsByYear W18092956142014 @default.
• W1809295614 countsByYear W18092956142016 @default.
• W1809295614 countsByYear W18092956142017 @default.
• W1809295614 countsByYear W18092956142018 @default.
• W1809295614 countsByYear W18092956142023 @default.
• W1809295614 crossrefType "journal-article" @default.
• W1809295614 hasAuthorship W1809295614A5032220933 @default.
• W1809295614 hasAuthorship W1809295614A5054510818 @default.
• W1809295614 hasBestOaLocation W18092956141 @default.
• W1809295614 hasConcept C104317684 @default.
• W1809295614 hasConcept C106358424 @default.
• W1809295614 hasConcept C132351222 @default.
• W1809295614 hasConcept C140704245 @default.
• W1809295614 hasConcept C159047783 @default.
• W1809295614 hasConcept C202751555 @default.
• W1809295614 hasConcept C207001950 @default.
• W1809295614 hasConcept C2522874641 @default.
• W1809295614 hasConcept C2781053568 @default.
• W1809295614 hasConcept C33602714 @default.
• W1809295614 hasConcept C35693153 @default.
• W1809295614 hasConcept C54355233 @default.
• W1809295614 hasConcept C60987743 @default.
• W1809295614 hasConcept C81885089 @default.
• W1809295614 hasConcept C86803240 @default.
• W1809295614 hasConcept C89423630 @default.
• W1809295614 hasConceptScore W1809295614C104317684 @default.
• W1809295614 hasConceptScore W1809295614C106358424 @default.
• W1809295614 hasConceptScore W1809295614C132351222 @default.
• W1809295614 hasConceptScore W1809295614C140704245 @default.
• W1809295614 hasConceptScore W1809295614C159047783 @default.
• W1809295614 hasConceptScore W1809295614C202751555 @default.
• W1809295614 hasConceptScore W1809295614C207001950 @default.
• W1809295614 hasConceptScore W1809295614C2522874641 @default.
• W1809295614 hasConceptScore W1809295614C2781053568 @default.
• W1809295614 hasConceptScore W1809295614C33602714 @default.
• W1809295614 hasConceptScore W1809295614C35693153 @default.
• W1809295614 hasConceptScore W1809295614C54355233 @default.
• W1809295614 hasConceptScore W1809295614C60987743 @default.
• W1809295614 hasConceptScore W1809295614C81885089 @default.
• W1809295614 hasConceptScore W1809295614C86803240 @default.
• W1809295614 hasConceptScore W1809295614C89423630 @default.
• W1809295614 hasIssue "6" @default.
• W1809295614 hasLocation W18092956141 @default.
• W1809295614 hasLocation W18092956142 @default.
• W1809295614 hasLocation W18092956143 @default.
• W1809295614 hasLocation W18092956144 @default.
• W1809295614 hasOpenAccess W1809295614 @default.

• next