FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1809395615> ?p ?o ?g. }

• W1809395615 abstract "Deciphering effective ways to suppress tumor progression and to overcome acquired apoptosis resistance of tumor cells are major challenges in the tumor therapy field. We propose a new concept by which tumor progression can be suppressed by manipulating tumor cell identity. In this study, we examined the effect of ER stress on apoptosis resistant tumorous cells in a Caenorhabditis elegans germline tumor model. We discovered that ER stress suppressed the progression of the lethal germline tumor by activating the ER stress sensor IRE-1. This suppression was associated with the induction of germ cell transdifferentiation into ectopic somatic cells. Strikingly, transdifferentiation of the tumorous germ cells restored their ability to execute apoptosis and enabled their subsequent removal from the gonad. Our results indicate that tumor cell transdifferentiation has the potential to combat cancer and overcome the escape of tumor cells from the cell death machinery." @default.
• W1809395615 created "2016-06-24" @default.
• W1809395615 creator A5000241444 @default.
• W1809395615 creator A5034023658 @default.
• W1809395615 creator A5052831172 @default.
• W1809395615 creator A5078955564 @default.
• W1809395615 date "2015-07-20" @default.
• W1809395615 modified "2023-10-17" @default.
• W1809395615 title "Transdifferentiation mediated tumor suppression by the endoplasmic reticulum stress sensor IRE-1 in C. elegans" @default.
• W1809395615 cites W1846312500 @default.
• W1809395615 cites W1905806846 @default.
• W1809395615 cites W195059524 @default.
• W1809395615 cites W1954154760 @default.
• W1809395615 cites W1964730983 @default.
• W1809395615 cites W1965843055 @default.
• W1809395615 cites W1969962178 @default.
• W1809395615 cites W1982173655 @default.
• W1809395615 cites W1986737010 @default.
• W1809395615 cites W2002439304 @default.
• W1809395615 cites W2022679584 @default.
• W1809395615 cites W2031132185 @default.
• W1809395615 cites W2033498063 @default.
• W1809395615 cites W2034269086 @default.
• W1809395615 cites W2051303735 @default.
• W1809395615 cites W2052053410 @default.
• W1809395615 cites W2052569390 @default.
• W1809395615 cites W2056501152 @default.
• W1809395615 cites W2057612890 @default.
• W1809395615 cites W2058051854 @default.
• W1809395615 cites W2063078301 @default.
• W1809395615 cites W2080901528 @default.
• W1809395615 cites W2087345704 @default.
• W1809395615 cites W2096005449 @default.
• W1809395615 cites W2102085111 @default.
• W1809395615 cites W2110015559 @default.
• W1809395615 cites W2117692326 @default.
• W1809395615 cites W2127244622 @default.
• W1809395615 cites W2128179994 @default.
• W1809395615 cites W2128870191 @default.
• W1809395615 cites W2129160653 @default.
• W1809395615 cites W2141244689 @default.
• W1809395615 cites W2141668423 @default.
• W1809395615 cites W2143087417 @default.
• W1809395615 cites W2144487953 @default.
• W1809395615 cites W2154166770 @default.
• W1809395615 cites W2155163967 @default.
• W1809395615 cites W2155945227 @default.
• W1809395615 cites W2157360354 @default.
• W1809395615 cites W2166432051 @default.
• W1809395615 cites W2166696251 @default.
• W1809395615 cites W2192080449 @default.
• W1809395615 cites W3012640819 @default.
• W1809395615 cites W4241031272 @default.
• W1809395615 doi "https://doi.org/10.7554/elife.08005" @default.
• W1809395615 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4507713" @default.
• W1809395615 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26192965" @default.
• W1809395615 hasPublicationYear "2015" @default.
• W1809395615 type Work @default.
• W1809395615 sameAs 1809395615 @default.
• W1809395615 citedByCount "10" @default.
• W1809395615 countsByYear W18093956152016 @default.
• W1809395615 countsByYear W18093956152017 @default.
• W1809395615 countsByYear W18093956152019 @default.
• W1809395615 countsByYear W18093956152020 @default.
• W1809395615 countsByYear W18093956152021 @default.
• W1809395615 countsByYear W18093956152022 @default.
• W1809395615 crossrefType "journal-article" @default.
• W1809395615 hasAuthorship W1809395615A5000241444 @default.
• W1809395615 hasAuthorship W1809395615A5034023658 @default.
• W1809395615 hasAuthorship W1809395615A5052831172 @default.
• W1809395615 hasAuthorship W1809395615A5078955564 @default.
• W1809395615 hasBestOaLocation W18093956151 @default.
• W1809395615 hasConcept C104317684 @default.
• W1809395615 hasConcept C121608353 @default.
• W1809395615 hasConcept C134305767 @default.
• W1809395615 hasConcept C139447449 @default.
• W1809395615 hasConcept C158617107 @default.
• W1809395615 hasConcept C190283241 @default.
• W1809395615 hasConcept C2779256057 @default.
• W1809395615 hasConcept C28328180 @default.
• W1809395615 hasConcept C31573885 @default.
• W1809395615 hasConcept C502942594 @default.
• W1809395615 hasConcept C54355233 @default.
• W1809395615 hasConcept C60870556 @default.
• W1809395615 hasConcept C81885089 @default.
• W1809395615 hasConcept C86803240 @default.
• W1809395615 hasConcept C95444343 @default.
• W1809395615 hasConcept C97037327 @default.
• W1809395615 hasConceptScore W1809395615C104317684 @default.
• W1809395615 hasConceptScore W1809395615C121608353 @default.
• W1809395615 hasConceptScore W1809395615C134305767 @default.
• W1809395615 hasConceptScore W1809395615C139447449 @default.
• W1809395615 hasConceptScore W1809395615C158617107 @default.
• W1809395615 hasConceptScore W1809395615C190283241 @default.
• W1809395615 hasConceptScore W1809395615C2779256057 @default.
• W1809395615 hasConceptScore W1809395615C28328180 @default.
• W1809395615 hasConceptScore W1809395615C31573885 @default.
• W1809395615 hasConceptScore W1809395615C502942594 @default.
• W1809395615 hasConceptScore W1809395615C54355233 @default.
• W1809395615 hasConceptScore W1809395615C60870556 @default.

• next