Matches in SemOpenAlex for { <https://semopenalex.org/work/W1809788493> ?p ?o ?g. }
- W1809788493 endingPage "2528" @default.
- W1809788493 startingPage "2516" @default.
- W1809788493 abstract "Abstract Adult neurogenesis is a multistep process regulated by several extrinsic factors, including neurotrophins. Among them, little is known about the role of nerve growth factor (NGF) in the neurogenic niches of the mouse. Here we analyzed the biology of adult neural stem cells (NSCs) from the subventricular zone (SVZ) of AD11 anti-NGF transgenic mice, in which the expression of the recombinant antibody aD11 leads to a chronic postnatal neutralization of endogenous NGF. We showed that AD11-NSCs proliferate 10-fold less, with respect to their control counterparts, and display a significant impairment in their ability to differentiate into β-tubulin positive neurons. We found a considerable reduction in the number of SVZ progenitors and neuroblasts also in vivo, which correlates with a lower number of newborn neurons in the olfactory bulbs of AD11 mice and a severe deficit in the ability of these mice to discriminate between different odors. We also demonstrated that, in AD11 mice, the morphology of both SVZ-resident and neurosphere-derived astrocytes is significantly altered. We were able to reproduce the AD11 phenotype in vitro, by acutely treating wild type NSCs with the anti-NGF antibody, further demonstrating that both the proliferation and the differentiation defects are due to the NGF deprivation. Consistently, the proliferative impairment of AD11 progenitors, as well as the atrophic morphology of AD11 astrocytes, can be partly rescued in vitro and in vivo by exogenous NGF addition. Altogether, our results demonstrate a causal link between NGF signaling and proper proliferation and differentiation of neural stem cells from the SVZ. Stem Cells 2014;32:2516–2528" @default.
- W1809788493 created "2016-06-24" @default.
- W1809788493 creator A5014928136 @default.
- W1809788493 creator A5020786321 @default.
- W1809788493 creator A5027510894 @default.
- W1809788493 creator A5031660873 @default.
- W1809788493 creator A5036135292 @default.
- W1809788493 creator A5058045156 @default.
- W1809788493 creator A5070738249 @default.
- W1809788493 creator A5080599656 @default.
- W1809788493 creator A5083437438 @default.
- W1809788493 creator A5085903867 @default.
- W1809788493 creator A5091036553 @default.
- W1809788493 date "2014-08-18" @default.
- W1809788493 modified "2023-10-02" @default.
- W1809788493 title "Neutralization of Nerve Growth Factor Impairs Proliferation and Differentiation of Adult Neural Progenitors in the Subventricular Zone" @default.
- W1809788493 cites W1872191299 @default.
- W1809788493 cites W1966534777 @default.
- W1809788493 cites W1974791004 @default.
- W1809788493 cites W1975019629 @default.
- W1809788493 cites W1982780398 @default.
- W1809788493 cites W1983878566 @default.
- W1809788493 cites W1984866761 @default.
- W1809788493 cites W1989346221 @default.
- W1809788493 cites W1991098179 @default.
- W1809788493 cites W1996548845 @default.
- W1809788493 cites W2002718147 @default.
- W1809788493 cites W2013770936 @default.
- W1809788493 cites W2014797861 @default.
- W1809788493 cites W2015387012 @default.
- W1809788493 cites W2018235103 @default.
- W1809788493 cites W2032781065 @default.
- W1809788493 cites W2032847029 @default.
- W1809788493 cites W2032888964 @default.
- W1809788493 cites W2036738726 @default.
- W1809788493 cites W2037118555 @default.
- W1809788493 cites W2037177143 @default.
- W1809788493 cites W2043655216 @default.
- W1809788493 cites W2052144021 @default.
- W1809788493 cites W2057608998 @default.
- W1809788493 cites W2057737598 @default.
- W1809788493 cites W2064386004 @default.
- W1809788493 cites W2066944439 @default.
- W1809788493 cites W2086641148 @default.
- W1809788493 cites W2092141425 @default.
- W1809788493 cites W2095842386 @default.
- W1809788493 cites W2102367498 @default.
- W1809788493 cites W2107277218 @default.
- W1809788493 cites W2108523937 @default.
- W1809788493 cites W2110159269 @default.
- W1809788493 cites W2112689297 @default.
- W1809788493 cites W2119624278 @default.
- W1809788493 cites W2122318491 @default.
- W1809788493 cites W2124366353 @default.
- W1809788493 cites W2132367339 @default.
- W1809788493 cites W2134031827 @default.
- W1809788493 cites W2135046848 @default.
- W1809788493 cites W2138009201 @default.
- W1809788493 cites W2150083975 @default.
- W1809788493 cites W2151362269 @default.
- W1809788493 cites W2156836944 @default.
- W1809788493 cites W2161722802 @default.
- W1809788493 cites W2171502370 @default.
- W1809788493 cites W2496500541 @default.
- W1809788493 cites W313255239 @default.
- W1809788493 doi "https://doi.org/10.1002/stem.1744" @default.
- W1809788493 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24806549" @default.
- W1809788493 hasPublicationYear "2014" @default.
- W1809788493 type Work @default.
- W1809788493 sameAs 1809788493 @default.
- W1809788493 citedByCount "30" @default.
- W1809788493 countsByYear W18097884932014 @default.
- W1809788493 countsByYear W18097884932015 @default.
- W1809788493 countsByYear W18097884932016 @default.
- W1809788493 countsByYear W18097884932017 @default.
- W1809788493 countsByYear W18097884932018 @default.
- W1809788493 countsByYear W18097884932019 @default.
- W1809788493 countsByYear W18097884932020 @default.
- W1809788493 countsByYear W18097884932021 @default.
- W1809788493 countsByYear W18097884932022 @default.
- W1809788493 countsByYear W18097884932023 @default.
- W1809788493 crossrefType "journal-article" @default.
- W1809788493 hasAuthorship W1809788493A5014928136 @default.
- W1809788493 hasAuthorship W1809788493A5020786321 @default.
- W1809788493 hasAuthorship W1809788493A5027510894 @default.
- W1809788493 hasAuthorship W1809788493A5031660873 @default.
- W1809788493 hasAuthorship W1809788493A5036135292 @default.
- W1809788493 hasAuthorship W1809788493A5058045156 @default.
- W1809788493 hasAuthorship W1809788493A5070738249 @default.
- W1809788493 hasAuthorship W1809788493A5080599656 @default.
- W1809788493 hasAuthorship W1809788493A5083437438 @default.
- W1809788493 hasAuthorship W1809788493A5085903867 @default.
- W1809788493 hasAuthorship W1809788493A5091036553 @default.
- W1809788493 hasBestOaLocation W18097884931 @default.
- W1809788493 hasConcept C136834591 @default.
- W1809788493 hasConcept C160539049 @default.
- W1809788493 hasConcept C169760540 @default.
- W1809788493 hasConcept C170493617 @default.