FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W180994966> ?p ?o ?g. }

• W180994966 endingPage "207" @default.
• W180994966 startingPage "191" @default.
• W180994966 abstract "Publisher Summary Inositol 1,4,5-trisphosphate receptors (IP 3 Rs) are a family of ligand-gated channels that release calcium primarily from endoplasmic reticulum stores. To elucidate the structure and regulation of IP 3 R channels at the molecular level is of paramount importance to understand the disease progression and the development of targeted therapeutics. This chapter discusses and examines the molecular architecture of the transmembrane domains and the channel pore. The IP 3 R channel is a tetramer that forms a single ion conduction pore. It is generally accepted that all cells express at least one IP 3 R isoform and most tissues express a combination of isoforms, which can form homo- and heterotetramers. There are two atomic resolution structures of parts of the IP 3 R protein: the ligand binding domain, and the suppressor region. The ligand binding domain is formed by a pocket sandwiched between a beta-trefoil domain and an armadillo-like repeat. The suppressor domain also has a beta-trefoil like fold, and likely interacts with and stabilizes the IP 3 binding core. Significant advances are made in understanding structural and functional relationships in the channel domain using biochemistry and electrophysiology." @default.
• W180994966 created "2016-06-24" @default.
• W180994966 creator A5077835261 @default.
• W180994966 date "2010-01-01" @default.
• W180994966 modified "2023-09-23" @default.
• W180994966 title "Molecular Architecture of the Inositol 1,4,5-Trisphosphate Receptor Pore" @default.
• W180994966 cites W1486474082 @default.
• W180994966 cites W1970969385 @default.
• W180994966 cites W1975085370 @default.
• W180994966 cites W1976746355 @default.
• W180994966 cites W1981011106 @default.
• W180994966 cites W1982289450 @default.
• W180994966 cites W1984843607 @default.
• W180994966 cites W2001907971 @default.
• W180994966 cites W2002378144 @default.
• W180994966 cites W2003468829 @default.
• W180994966 cites W2003962250 @default.
• W180994966 cites W2005496553 @default.
• W180994966 cites W2007781466 @default.
• W180994966 cites W2008602342 @default.
• W180994966 cites W2015286444 @default.
• W180994966 cites W2020828897 @default.
• W180994966 cites W2027630654 @default.
• W180994966 cites W2030631891 @default.
• W180994966 cites W2031183644 @default.
• W180994966 cites W2032734987 @default.
• W180994966 cites W2035310732 @default.
• W180994966 cites W2035658391 @default.
• W180994966 cites W2037842536 @default.
• W180994966 cites W2040213270 @default.
• W180994966 cites W2044219698 @default.
• W180994966 cites W2046492840 @default.
• W180994966 cites W2052018007 @default.
• W180994966 cites W2059230624 @default.
• W180994966 cites W2060802834 @default.
• W180994966 cites W2061225022 @default.
• W180994966 cites W2062985112 @default.
• W180994966 cites W2066261176 @default.
• W180994966 cites W2067192885 @default.
• W180994966 cites W2070053976 @default.
• W180994966 cites W2070964791 @default.
• W180994966 cites W2073297263 @default.
• W180994966 cites W2073545060 @default.
• W180994966 cites W2081082836 @default.
• W180994966 cites W2083688230 @default.
• W180994966 cites W2084742082 @default.
• W180994966 cites W2085913208 @default.
• W180994966 cites W2086450825 @default.
• W180994966 cites W2089930510 @default.
• W180994966 cites W2093241572 @default.
• W180994966 cites W2096199252 @default.
• W180994966 cites W2100295031 @default.
• W180994966 cites W2106207499 @default.
• W180994966 cites W2115900546 @default.
• W180994966 cites W2120600363 @default.
• W180994966 cites W2123323648 @default.
• W180994966 cites W2123849347 @default.
• W180994966 cites W2125127422 @default.
• W180994966 cites W2140375398 @default.
• W180994966 cites W2143070723 @default.
• W180994966 cites W2144553803 @default.
• W180994966 cites W2144922739 @default.
• W180994966 cites W2146387077 @default.
• W180994966 cites W2150835488 @default.
• W180994966 cites W2163629303 @default.
• W180994966 cites W2164829352 @default.
• W180994966 cites W2172253369 @default.
• W180994966 doi "https://doi.org/10.1016/s1063-5823(10)66009-7" @default.
• W180994966 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22353481" @default.
• W180994966 hasPublicationYear "2010" @default.
• W180994966 type Work @default.
• W180994966 sameAs 180994966 @default.
• W180994966 citedByCount "7" @default.
• W180994966 countsByYear W1809949662013 @default.
• W180994966 countsByYear W1809949662014 @default.
• W180994966 countsByYear W1809949662015 @default.
• W180994966 countsByYear W1809949662017 @default.
• W180994966 crossrefType "book-chapter" @default.
• W180994966 hasAuthorship W180994966A5077835261 @default.
• W180994966 hasConcept C123657996 @default.
• W180994966 hasConcept C142362112 @default.
• W180994966 hasConcept C153349607 @default.
• W180994966 hasConcept C170493617 @default.
• W180994966 hasConcept C185592680 @default.
• W180994966 hasConcept C2777427919 @default.
• W180994966 hasConcept C41008148 @default.
• W180994966 hasConcept C55493867 @default.
• W180994966 hasConceptScore W180994966C123657996 @default.
• W180994966 hasConceptScore W180994966C142362112 @default.
• W180994966 hasConceptScore W180994966C153349607 @default.
• W180994966 hasConceptScore W180994966C170493617 @default.
• W180994966 hasConceptScore W180994966C185592680 @default.
• W180994966 hasConceptScore W180994966C2777427919 @default.
• W180994966 hasConceptScore W180994966C41008148 @default.
• W180994966 hasConceptScore W180994966C55493867 @default.
• W180994966 hasLocation W1809949661 @default.
• W180994966 hasLocation W1809949662 @default.
• W180994966 hasOpenAccess W180994966 @default.

• next