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- W1810076656 abstract "Introduction Notch signaling pathway has been shown to be dysregulated in placentas with preeclampsia, but there has been a lack of studies on methylation of Notch family genes in this disorder. Objectives: To investigate the methylation status of DLL 1 and Notch 1 and expression of those proteins in placenta with preeclampsia. Methods We therefore executed methylation-specific polymerase chain reaction and immunostaining for Notch 1 receptor and the activating ligand, Delta-like (DLL) 1, with placental tissues from cases of preeclampsia (early-onset, n =18; late-onset, n =19) and other placental disorders, including maternal complications such as diabetes mellitus and collagen disease (n = 10), fetal growth restriction ( n =17), fetal anomaly ( n =23), preterm birth ( n =15), miscarriage ( n =25), and hydatidiform moles ( n =9) as well as term births ( n =12). Results The frequency of DLL1 methylation was higher in early-onset preeclamptic placentas (61%) than the other subjects (0–36%; P ⩽0.016). Appreciable samples (36%) of miscarriage also represented DLL1 methylation. None of the samples studied showed Notch 1 methylation. On gestational period-matched analysis, the rate of DLL1 methylation was higher in early-onset preeclampsia (83.3%) than preterm birth (13.3%; P Conclusion Altered Notch signaling via methylation of DLL1 is likely involved in possible disease-related mechanisms of early-onset preeclampsia. Alternatively, DLL1 methylation in early-onset preeclampsia could be a manifestation of a lack of placental maturation, similar to miscarriage." @default.
- W1810076656 created "2016-06-24" @default.
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- W1810076656 date "2015-07-01" @default.
- W1810076656 modified "2023-09-27" @default.
- W1810076656 title "P87. Alteration of Delta-like ligand 1 and Notch 1 receptor in various placental disorders with special reference to early-onset preeclampsia" @default.
- W1810076656 doi "https://doi.org/10.1016/j.preghy.2015.07.106" @default.
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