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- W18100793 endingPage "476" @default.
- W18100793 startingPage "447" @default.
- W18100793 abstract "Blood coagulation is a complex process involving blood cell surfaces, plasma proteins, and inhibitory mechanisms. Many of the inhibitory mechanisms are associated with the blood vessel wall. The protein C pathway is one of the major mechanisms involved in controlling blood coagulation. The interaction of the protein C pathway with a highly simplified version of the major coagulation cascade is illustrated in Fig. 1. The blood clotting process occurs when tissue factor is exposed to blood. This triggers either factor X or factor IX activation. Factor IXa complexes with factor Villa to provide an alternative activation mechanism for factor X. Factor Xa, in complex with factor Va, generates thrombin which causes fibrin clots and platelet activation. All of these reactions proceed on the surface of activated or damaged cells when the membrane phospholipid asymmetry is perturbed, resulting in exposure of negatively charged phospholipids. These clotting reactions are offset by natural anticoagulant mechanisms, the most important of which are thought to include the tissue factor pathway inhibitor (Chap. 15), antithrombin-heparin (Chap. 9) and the protein C anticoagulant pathway (depicted in Fig. 1)." @default.
- W18100793 created "2016-06-24" @default.
- W18100793 creator A5056607779 @default.
- W18100793 date "1999-01-01" @default.
- W18100793 modified "2023-09-23" @default.
- W18100793 title "Natural Anticoagulants and Their Pathways" @default.
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