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- W181015035 abstract "The non-steroidal anti-inflammatory agents, besides their anti-inflammatory and analgesic properties, also cause gastrointestinal mucosal damage. Prostaglandins exert protective action in the gastrointestinal tract, but induce inflammation and pain. Since inflammatory reactions are observed in the early phase of gastric damage [1], substances which inhibit the acute inflammation via non-prostaglandin mechanisms might exert mucosal protective action. Some years ago we reported that pyrido-pyrimidine derivatives possess analgesic and anti-inflammatory properties and protect the gastric mucosa against damages induced by non-steroidal anti-inflammatory substances and necrotizing agents [2–4]. The aim of the present study is to demonstrate with further examples that structurally different compounds with antiphlogistic activity decrease gastric mucosal damage as well." @default.
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- W181015035 date "1992-01-01" @default.
- W181015035 modified "2023-09-27" @default.
- W181015035 title "Influence of different anti-inflammatory substances on ethanol- and indomethacin induced gastrointestinal mucosal damage" @default.
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- W181015035 doi "https://doi.org/10.1007/978-94-011-2982-4_39" @default.
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