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- W181041749 abstract "Background: Cohort studies have shown that nut consumption is strongly associated with a reduced risk of coronary heart disease (CHD). Intervention studies demonstrate that almonds reduce serum LDL-C. However, their documented reduction in LDL-C can only explain a proportion of the reduced CHD risk. Methods: Whole almonds, taken as snacks, were compared to low-saturated fat (<5% energy) whole-wheat muffins (control) in the therapeutic diets of subjects with hyperlipidemia. Twenty seven hyperlipidemic men and women each consumed three iso-energetic (mean 423kcal/d) supplements for 1 month. Supplements consisted of full-dose almonds (73±3g/d), half-dose almonds plus half-dose muffins, and full-dose muffins. In each phase, subjects were assessed at weeks 0, 2 and 4. Results: No baseline or treatment differences were seen in fasting serum glucose, insulin, C-peptide or calculated insulin resistance (HOMA-IR). However, creatinine corrected, 24-hour urinary C-peptide output, a marker of daily insulin secretion, was significantly reduced on both the half- and full-almond doses compared to the control (P=0.002 and P=0.004, respectively). Conclusion: Almond consumption reduced 24-hour insulin secretion. This may be a further metabolic advantage of nuts that in the long-term may help to explain the strong association between nuts and CHD risk reduction. Funding support: Almond Board of California" @default.
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- W181041749 date "2008-03-01" @default.
- W181041749 modified "2023-10-16" @default.
- W181041749 title "Effect of Almonds on Insulin Secretion and Insulin Resistance: A Randomized Controlled Cross‐over Trial" @default.
- W181041749 doi "https://doi.org/10.1096/fasebj.22.1_supplement.702.25" @default.
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