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- W1810721805 abstract "textabstractChronic respiratory failure develops over the years in many patients with chronic obstructivepulmonary disease (COPD). During exacerbations of COPD the gas-exchange is known todeteriorate in these patients. This acute-on-chronic respiratory failure may ultimately lead tohypercapnic coma. Mechanical ventilation has to be applied to maintain gas-exchange. As thistreatment does not affect the pathophysiological mechanisms leading to the respiratory failure,mechanical ventilation can only be considered as rescue therapy.Altered respiratory mechanics associated with COPD may hamper ventilatory support. For thesame reasons weaning from the ventilator is considered to be a cumbersome process, in manypatients requiring long-tenn ventilatory support. These altered respiratory mechanics can beelucidated in tenns of elastic recoil of the lung and airways resistance. In this chapter thesefeatures will be described with emphasis on spontaneous breathing as well as mechanicalventilation. Adaptations of equipment used for ventilatory support and weaning purposes thatmay improve ventilation and gas-exchange in COPD, will be reviewed. Finally an outline of theinvestigations described in this thesis will be given.The popUlation of patients that is the subject of this thesis consists of those who are sufferingfrom severe chronic airways obstruction in whom loss of elasticity of lung tissue may bepresent. Though COPD may not be the exactly right nomenclature for the condition present inall of those patients, it was applied to all patients because destruction of elastic tissue of a minordegree is difficult to demonstrate or exclude in a living person." @default.
- W1810721805 created "2016-06-24" @default.
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- W1810721805 date "1996-12-18" @default.
- W1810721805 modified "2023-09-22" @default.
- W1810721805 title "Controlled expiration in patients with chronic obstructive pulmonary disease on ventilatory support" @default.
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