FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1811043827> ?p ?o ?g. }

• W1811043827 endingPage "91" @default.
• W1811043827 startingPage "183" @default.
• W1811043827 abstract "Prostate cancer (PCa) is a heterogeneous tumour entity with known interindividual differences in biological behaviour regarding tumour aggressiveness and metastatic potentiaL To date, the prediction of the metastatic status of patients with PCa has not been possible. To identify the molecular causes behind these differences, the gene expression profiles of two cell lines (LNCaP and LNCaP C4-2) with different metastatic potentials were examined using DNA microarray technology.LNCaP and LNCaP C4-2 cells were cultured under standard conditions. RNA was isolated using Trizol extraction. After processing the total RNA according to the manufacturer's instructions, we performed Affymetrix GeneChip analysis with HG-U133A chips. Data analysis was performed using NetAffx, dChip, GenMAPP and OMIM software.After statistical evaluation of the raw data, we obtained a set of 158 differently expressed probe sets in the LNCaP and LNCaP C4-2 cells. The search for genes associated with proliferation, cell metabolism, growth factors, metastatic potential and tumour progression in this list revealed a number of 42 differently expressed probe sets. The comparison of this list of probe sets with the literature resulted in a list of 14 differently expressed genes which could well contribute to the metastatic potential and progression of PCa. Of these 14 genes only 6 (Cip1, IGF-1, NK4, CXCL 12, ILGF2R, RHOE) have already been associated with PCa, whereas the other 8 genes (FSTL-1, SOCS-2, Midkine, Thrombospondin 1, Secretory leukocyte protease inhibitor, Desmoglein 2, MLT 1, PTPRF) had not been previously related to PCa.DNA microarray technology offers the possibility of screening a large number of genes with regard to alterations in the expression level or mutations. In this study, we identified 14 genes that are most probably associated with the higher metastatic potential of LNCaP C4-2 cells as compared to LNCaP cells. Eight of these 14 genes are potential new molecular markers for assessing the metastatic potential of PCa, or may serve as therapeutical targets." @default.
• W1811043827 created "2016-06-24" @default.
• W1811043827 creator A5005760153 @default.
• W1811043827 creator A5030789668 @default.
• W1811043827 creator A5037303782 @default.
• W1811043827 creator A5038130664 @default.
• W1811043827 creator A5048419761 @default.
• W1811043827 creator A5052558333 @default.
• W1811043827 creator A5065543856 @default.
• W1811043827 creator A5067050215 @default.
• W1811043827 creator A5068548177 @default.
• W1811043827 date "2005-04-09" @default.
• W1811043827 modified "2023-10-16" @default.
• W1811043827 title "Identification of metastasis-associated genes in prostate cancer by genetic profiling of human prostate cancer cell lines." @default.
• W1811043827 cites W1368189 @default.
• W1811043827 cites W147591239 @default.
• W1811043827 cites W1482212046 @default.
• W1811043827 cites W1614806970 @default.
• W1811043827 cites W1959645321 @default.
• W1811043827 cites W1965464733 @default.
• W1811043827 cites W1978976783 @default.
• W1811043827 cites W1989401198 @default.
• W1811043827 cites W1989514276 @default.
• W1811043827 cites W1992108607 @default.
• W1811043827 cites W1992747704 @default.
• W1811043827 cites W2001471842 @default.
• W1811043827 cites W2004747469 @default.
• W1811043827 cites W2006754186 @default.
• W1811043827 cites W2007501886 @default.
• W1811043827 cites W2015711810 @default.
• W1811043827 cites W2017757468 @default.
• W1811043827 cites W2029427305 @default.
• W1811043827 cites W2033326908 @default.
• W1811043827 cites W2037917812 @default.
• W1811043827 cites W2054793295 @default.
• W1811043827 cites W2055015186 @default.
• W1811043827 cites W2055142461 @default.
• W1811043827 cites W2055474304 @default.
• W1811043827 cites W2056598421 @default.
• W1811043827 cites W2060684880 @default.
• W1811043827 cites W2064117760 @default.
• W1811043827 cites W2064164873 @default.
• W1811043827 cites W2064744782 @default.
• W1811043827 cites W2065654021 @default.
• W1811043827 cites W2072472184 @default.
• W1811043827 cites W2074282467 @default.
• W1811043827 cites W2075800153 @default.
• W1811043827 cites W2076822732 @default.
• W1811043827 cites W2088430561 @default.
• W1811043827 cites W2092068698 @default.
• W1811043827 cites W2094630214 @default.
• W1811043827 cites W2094790784 @default.
• W1811043827 cites W2100849207 @default.
• W1811043827 cites W2101485657 @default.
• W1811043827 cites W2102392974 @default.
• W1811043827 cites W2110669077 @default.
• W1811043827 cites W2115566490 @default.
• W1811043827 cites W2119930698 @default.
• W1811043827 cites W2132437351 @default.
• W1811043827 cites W2133699333 @default.
• W1811043827 cites W2141882870 @default.
• W1811043827 cites W2145030059 @default.
• W1811043827 cites W2147208333 @default.
• W1811043827 cites W2155509911 @default.
• W1811043827 cites W2156854438 @default.
• W1811043827 cites W2162147642 @default.
• W1811043827 cites W2169635726 @default.
• W1811043827 cites W2412791293 @default.
• W1811043827 cites W2417566863 @default.
• W1811043827 cites W2726730675 @default.
• W1811043827 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15816537" @default.
• W1811043827 hasPublicationYear "2005" @default.
• W1811043827 type Work @default.
• W1811043827 sameAs 1811043827 @default.
• W1811043827 citedByCount "40" @default.
• W1811043827 countsByYear W18110438272012 @default.
• W1811043827 countsByYear W18110438272013 @default.
• W1811043827 countsByYear W18110438272014 @default.
• W1811043827 countsByYear W18110438272015 @default.
• W1811043827 countsByYear W18110438272016 @default.
• W1811043827 countsByYear W18110438272017 @default.
• W1811043827 countsByYear W18110438272018 @default.
• W1811043827 countsByYear W18110438272019 @default.
• W1811043827 countsByYear W18110438272020 @default.
• W1811043827 countsByYear W18110438272021 @default.
• W1811043827 countsByYear W18110438272023 @default.
• W1811043827 crossrefType "journal-article" @default.
• W1811043827 hasAuthorship W1811043827A5005760153 @default.
• W1811043827 hasAuthorship W1811043827A5030789668 @default.
• W1811043827 hasAuthorship W1811043827A5037303782 @default.
• W1811043827 hasAuthorship W1811043827A5038130664 @default.
• W1811043827 hasAuthorship W1811043827A5048419761 @default.
• W1811043827 hasAuthorship W1811043827A5052558333 @default.
• W1811043827 hasAuthorship W1811043827A5065543856 @default.
• W1811043827 hasAuthorship W1811043827A5067050215 @default.
• W1811043827 hasAuthorship W1811043827A5068548177 @default.
• W1811043827 hasConcept C104317684 @default.
• W1811043827 hasConcept C121608353 @default.

• next