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- W1811334828 endingPage "1310" @default.
- W1811334828 startingPage "1307" @default.
- W1811334828 abstract "The HA-specific B cell repertoires of 12 to 14-day-old C.B20 and (C.B20 X B10.D2)F1 mice have been characterized and compared to those of BALB/c, B10.D2, and (BALB/c X B10.D2)F1 mice to assess the role of allotype-linked loci in the process of repertoire formation. Both C.B20 and (C.B20 X B10.D2)F1 neonates express repertoires similar to (BALB/c X B10.D2)F1s of the same age, and allotypic analysis indicates that nonparental clonotypes observed in (BALB/c X B10.D2)F1s at this developmental stage are derived predominantly from the B10.D2 parent. In conjunction, these findings indicate that: a) allotype-linked loci, although influential in repertoire formation, clearly interact with loci elsewhere in the genome to shape the expressed repertoire phenotype; b) developmental preference may exist among heterozygous individuals regarding the time at which particular elements of each parental VH haplotype are expressed; and c) the factors that control this preference are dictated by heritable elements unlinked to Ig allotype loci." @default.
- W1811334828 created "2016-06-24" @default.
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- W1811334828 date "1982-03-01" @default.
- W1811334828 modified "2023-09-23" @default.
- W1811334828 title "Multiple loci mediate B cell repertoire ontogeny: analysis of the hemagglutinin-specific repertoires in neonatal C.B20 and (C.B20 x B10.D2)F1 mice." @default.
- W1811334828 doi "https://doi.org/10.4049/jimmunol.128.3.1307" @default.
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