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- W1811344536 endingPage "10" @default.
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- W1811344536 abstract "Alcohol use and sexual risk behaviors are multidimensional phenomena involving many genetic and environmental factors. 5-HT transporter linked promoter region (5-HTTLPR) polymorphism constitutes an important factor affecting alcohol use problems and risky sexual behaviors. This paper narratively reviews studies on 5-HTTLPR polymorphism and its associations with alcohol use problems and sexual risk behaviors. We searched the electronic databases, PubMed, Ovid, and Google Scholar for articles using MeSH terms. Relevant articles were reviewed and eligible articles were selected for the study. Many studies have reported a significant but moderate association between 5-HTTLPR polymorphism and alcohol use problems. These studies have implicated the presence of at least one S allele to be associated with significant increases in alcohol use problems. Similarly, some studies associate the S allele with increased sexual risk behaviors. Effective alcohol cessation initiatives and STI/HIV prevention programs should be modified to account for 5-HTTLPR polymorphism before planning interventions; genetic effects could moderate the intervention effect." @default.
- W1811344536 created "2016-06-24" @default.
- W1811344536 creator A5006412529 @default.
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- W1811344536 creator A5038663235 @default.
- W1811344536 creator A5039561102 @default.
- W1811344536 creator A5078153537 @default.
- W1811344536 date "2015-09-04" @default.
- W1811344536 modified "2023-10-10" @default.
- W1811344536 title "A review of 5-HT transporter linked promoter region (5-HTTLPR) polymorphism and associations with alcohol use problems and sexual risk behaviors" @default.
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- W1811344536 doi "https://doi.org/10.1007/s12687-015-0253-1" @default.
- W1811344536 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4715809" @default.
- W1811344536 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26338666" @default.
- W1811344536 hasPublicationYear "2015" @default.
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