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- W1811602482 abstract "This thesis is mainly concerned with the influence of substrate stiffness on periodontal ligament stem cells (PDLSCs) and stem cells from the apical papilla (SCAPs). PDLSCs and SCAPs are stem cells from dental tissues which are known to be a valuable source for regenerative procedures. The substrate stiffness is an important factor to promote the differentiation of stem cells to specific cell lineage. For example, stiff substrate induces the osteogenic differentiation of mesenchymal stem cells (MSCs) and stem cells from human exfoliated deciduous teeth (SHED), while soft matrix promoted the differentiation of dental follicle cells (DFCs) into the osteogenic lineage. In this study, PDLSCs and SCAPs were characterized in terms of stem cell properties. The characterization of PDLSCs and SCAPs which were obtained from different isolation methods and donors were comparable. However, the strongest mineralization was observed in PDLSCs and SCAPs which were isolated from the same tooth. Subsequently, polyacrylamide (PA) substrates with 3 different stiffness; stiff, medium and soft, were used to determine the influence of matrix stiffnesses on PDLSCs and SCAPs. Here, the matrix stiffness could not promote the osteogenic differentiation of PDLSCs and SCAPs. However, soft substrate tended to induce PDLSCs, while stiff substrate tended to promote SCAPs into osteogenic lineage, which is similar to DFCs and SHED respectively. Interestingly, soft matrix induced both PDLSCs and SCAPs into adipocytes, which is similar to MSCs." @default.
- W1811602482 created "2016-06-24" @default.
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- W1811602482 date "2015-03-24" @default.
- W1811602482 modified "2023-09-26" @default.
- W1811602482 title "The influence of substrate stiffness on the osteogenic differentiation of stem- and progenitor cells from dental tissue" @default.
- W1811602482 hasPublicationYear "2015" @default.
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