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• W1812202403 abstract "Abstract Indolicidin is a tridecapeptide amide isolated from the cytoplasmic granules of bovine neutrophils. It has potent, broad spectrum microbicidal activities in vitro that are thought to be related to the membrane-disruptive properties of the peptide. Based on the putative membrane-targeted mode of action, we postulated that indolicidin would be active against HIV-1, an enveloped virus. Indolicidin was reproducibly virucidal against HIV-1 at a concentration of 333 μg/mL (174 μM) with a 50% inhibitory dose between 67 and 100 μg/mL. At 37°, killing was rapid with &gt;50% killing of HIV occurring within 5 min, and nearly 100% viral inactivation achieved by 60 min. The anti-HIV activity of indolicidin was temperature-sensitive, a finding consistent with a membrane-mediated antiviral mechanism. Parallel experiments revealed that indolicidin lysed cultured lymphoblastoid cells at concentrations similar to those required for antiviral activity. However, a des-R13-amide indolicidin analog (R12-OH), previously shown to have less antibacterial activity than indolicidin, was significantly less active against HIV and was non-toxic to lymphoid target cells at concentrations up to 333 μg/mL, the highest level tested." @default.
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• W1812202403 date "1998-01-01" @default.
• W1812202403 modified "2023-10-13" @default.
• W1812202403 title "Anti-HIV-1 activity of indolicidin, an antimicrobial peptide from neutrophils" @default.
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• W1812202403 doi "https://doi.org/10.1002/jlb.63.1.94" @default.
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