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• W1812291985 abstract "ABSTRACT 1.) Binding studies in vitro and in vivo have provided little evidence for changes in the binding of opiates to their receptors during chronic treatment with these drugs. Some small changes may occur, but they appear to be unrelated to the development of tolerance and dependence. 2.) The role of endorphins in the development of opiate tolerance/ dependence is as yet unclear. Some evidence is available for the assumption that long term opiate treatment may be associated with a deficiency of the endorphinergic system. 3.) Apparent correlates of the entire addiction cycle can be observed at the single neurone level and indicate that adjustments of the chemical sensitivity of the postsynaptic membrane take place during chronic opiate action. 4.) The majority of data suggest that the main adaptive changes to chronic opiate action do not occur at the level of the opiate recognition site but in the opiate effector system. Development of non-specific supersensitivity to transmitters, as a consequence of these adaptive changes, seems to represent a basic mechanism underlying the development of tolerance and dependence to opiates." @default.
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• W1812291985 date "1979-01-01" @default.
• W1812291985 modified "2023-09-23" @default.
• W1812291985 title "Opiate Receptors, Their Endogenous Ligands and the Development of Tolerance/Dependence" @default.
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• W1812291985 doi "https://doi.org/10.1016/b978-0-08-023191-4.50010-6" @default.
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