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- W1812298061 abstract "The mammalian target of rapamycin (mTOR) plays an important role in cardiac development and function. Inhibition of mTOR by rapamycin has been shown to attenuate pathological cardiac hypertrophy and improve the function of aging heart, accompanied by an inhibition of the cardiac proteasome activity. The current study aimed to determine the potential mechanism(s) by which mTOR inhibition modulates cardiac proteasome. Inhibition of mTOR by rapamycin was found to reduce primarily the immunoproteasome in both H9c2 cells in vitro and mouse heart in vivo, without significant effect on the constitutive proteasome and protein ubiquitination. Concurrent with the reduction of the immunoproteasome, rapamycin reduced two important inflammatory response pathways, the NF-κB and Stat3 signaling. In addition, rapamycin attenuated the induction of the immunoproteasome in H9c2 cells by inflammatory cytokines, including INFγ and TNFα, by suppressing NF-κB signaling. These data indicate that rapamycin indirectly modulated immunoproteasome through the suppression of inflammatory response pathways. Lastly, the role of the immunoproteasome during the development of cardiac hypertrophy was investigated. Administration of a specific inhibitor of the immunoproteasome ONX 0914 attenuated isoproterenol-induced cardiac hypertrophy, suggesting that the immunoproteasome may be involved in the development of cardiac hypertrophy and therefore could be a therapeutic target. In conclusion, rapamycin inhibits the immunoproteasome through its effect on the inflammatory signaling pathways and the immunoproteasome could be a potential therapeutic target for pathological cardiac hypertrophy." @default.
- W1812298061 created "2016-06-24" @default.
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- W1812298061 creator A5066999889 @default.
- W1812298061 date "2015-09-01" @default.
- W1812298061 modified "2023-10-03" @default.
- W1812298061 title "The mammalian target of rapamycin modulates the immunoproteasome system in the heart" @default.
- W1812298061 cites W1471166809 @default.
- W1812298061 cites W1510925955 @default.
- W1812298061 cites W1554030075 @default.
- W1812298061 cites W1557117331 @default.
- W1812298061 cites W1608741224 @default.
- W1812298061 cites W1704776725 @default.
- W1812298061 cites W1960514362 @default.
- W1812298061 cites W1969157667 @default.
- W1812298061 cites W1970550717 @default.
- W1812298061 cites W1973161062 @default.
- W1812298061 cites W1974010669 @default.
- W1812298061 cites W1977718987 @default.
- W1812298061 cites W1981125871 @default.
- W1812298061 cites W1987011447 @default.
- W1812298061 cites W1988645175 @default.
- W1812298061 cites W1989398460 @default.
- W1812298061 cites W2000091638 @default.
- W1812298061 cites W2005522614 @default.
- W1812298061 cites W2007065684 @default.
- W1812298061 cites W2007871968 @default.
- W1812298061 cites W2008020112 @default.
- W1812298061 cites W2009483242 @default.
- W1812298061 cites W2009966467 @default.
- W1812298061 cites W2011253818 @default.
- W1812298061 cites W2013513564 @default.
- W1812298061 cites W2019478598 @default.
- W1812298061 cites W2020920210 @default.
- W1812298061 cites W2022544791 @default.
- W1812298061 cites W2023867071 @default.
- W1812298061 cites W2025761448 @default.
- W1812298061 cites W2027630003 @default.
- W1812298061 cites W2029530051 @default.
- W1812298061 cites W2031173888 @default.
- W1812298061 cites W2033551274 @default.
- W1812298061 cites W2036782018 @default.
- W1812298061 cites W2040938702 @default.
- W1812298061 cites W2041850341 @default.
- W1812298061 cites W2051250936 @default.
- W1812298061 cites W2056717322 @default.
- W1812298061 cites W2057318044 @default.
- W1812298061 cites W2057832589 @default.
- W1812298061 cites W2059501796 @default.
- W1812298061 cites W2060293553 @default.
- W1812298061 cites W2065322400 @default.
- W1812298061 cites W2066013797 @default.
- W1812298061 cites W2071191421 @default.
- W1812298061 cites W2072510345 @default.
- W1812298061 cites W2074003586 @default.
- W1812298061 cites W2074432271 @default.
- W1812298061 cites W2076493816 @default.
- W1812298061 cites W2078275713 @default.
- W1812298061 cites W2081992157 @default.
- W1812298061 cites W2086287235 @default.
- W1812298061 cites W2091597079 @default.
- W1812298061 cites W2092171265 @default.
- W1812298061 cites W2103460528 @default.
- W1812298061 cites W2111524632 @default.
- W1812298061 cites W2112807025 @default.
- W1812298061 cites W2114741231 @default.
- W1812298061 cites W2115568781 @default.
- W1812298061 cites W2116331361 @default.
- W1812298061 cites W2120706382 @default.
- W1812298061 cites W2122515314 @default.
- W1812298061 cites W2123219048 @default.
- W1812298061 cites W2127063807 @default.
- W1812298061 cites W2131587773 @default.
- W1812298061 cites W2134738156 @default.
- W1812298061 cites W2136662222 @default.
- W1812298061 cites W2142304810 @default.
- W1812298061 cites W2143225930 @default.
- W1812298061 cites W2143804524 @default.
- W1812298061 cites W2151970753 @default.
- W1812298061 cites W2154527891 @default.
- W1812298061 cites W2154602568 @default.
- W1812298061 cites W2155810842 @default.
- W1812298061 cites W2157360228 @default.
- W1812298061 cites W2160880055 @default.
- W1812298061 cites W2165876402 @default.
- W1812298061 cites W2172004363 @default.
- W1812298061 cites W2405643112 @default.
- W1812298061 cites W4312958931 @default.
- W1812298061 doi "https://doi.org/10.1016/j.yjmcc.2015.07.027" @default.
- W1812298061 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26239133" @default.
- W1812298061 hasPublicationYear "2015" @default.
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