FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1812305246> ?p ?o ?g. }

• W1812305246 abstract "Aims: The etiology of esophageal squamous cell carcinoma (ESCC) in the high risk areas is largely unknown and a few environmental risk factors which have been identified do not explain its oddly high incidence in esophageal cancer belt. The aims of this thesis were to investigate the association of opium/tobacco consumption, serologic gastric atrophy, gastric mucosa-associated microbiota and contact with farm animals with the risk of ESCC. Methods: The population of Golestan Province in northeastern Iran has very high rates of ESCC. From 2003 to 2007, we administered a validated structured questionnaire to 300 incident ESCC cases and 571 controls. Controls were matched to cases for neighborhood of residence, age (± 2 years), and sex. We measured serum pepsinogen I and II among 293 incident cases and 524 matched controls. Conditional logistic regression models were applied to calculate odds ratios (ORs) and 95% confidence intervals (CIs) adjusted for potential confounders. Furthermore we obtained a frozen gastric tissue biopsy from subjects with ESCC, esophageal squamous dysplasia, mid esophagus esophagitis, and age/sex-matched endoscopy clinic controls with healthy esophagus. To characterize bacterial lineage present in gastric mucosa, we performed a multiplex sequencing with GS-FLX Titanium targeting 16S rRNA. Results: Risk of ESCC was increased in those who used opium only (OR = 2.12, 95% CI: 1.21 3.74), and in those who used both tobacco and opium (2.35, 95% CI: 1.50 3.67). All forms of tobacco use (cigarettes, hookah, and nass) were associated with higher ESCC risk. Gastric atrophy (defined by a validated criterion, pepsinogen I <55 μg/dl) was associated with a two-fold increased risk (OR = 2.01, 95% CI: 1.18 3.45) of ESCC in the absence of non-atrophic pangastritis (defined as pepsinogen II < 11.8 μg/dl). Sequencing of 16S rRNA in gastric biopsy samples resulted 2075 operational taxonomic units (OTUs). Conditional logistic regression model based on principal coordinate analysis (PCoA) showed a marginal variation in pattern of gastric microbiota using Unifrac (p = 0.004) and weighted Unifrac distances (p = 0.018) between subjects with esophageal cancer or dysplasia and controls. No such difference between subjects with mid-esophagitis and controls was observed. Among four groups of farm animals (equines, ruminants, domestic canine and poultry) contact with ruminants was associated with an 8-fold increase in risk of ESCC. This association stayed stable when duration and level of contact were considered. Conclusions: Though opium and tobacco consumption are associated with the risk of ESCC in the study area, they do not explain the extreme high incidence in northern Iran. Changes in gastric environment might be linked to ESCC risk as fundal atrophy may increase the risk for ESCC and pattern of gastric microbiota differs in patients with esophageal squamous dysplasia (and ESCC) from subjects with normal esophagus. The observed relationship between lifelong contact with ruminants and ESCC needs further investigation." @default.
• W1812305246 created "2016-06-24" @default.
• W1812305246 creator A5050934002 @default.
• W1812305246 date "2013-09-11" @default.
• W1812305246 modified "2023-09-27" @default.
• W1812305246 title "Risk factors for esophageal squamous cell carcinoma" @default.
• W1812305246 cites W116762882 @default.
• W1812305246 cites W1508798853 @default.
• W1812305246 cites W1535149704 @default.
• W1812305246 cites W1594560215 @default.
• W1812305246 cites W1595209989 @default.
• W1812305246 cites W1863244557 @default.
• W1812305246 cites W1899695363 @default.
• W1812305246 cites W1901609175 @default.
• W1812305246 cites W191178295 @default.
• W1812305246 cites W1916801516 @default.
• W1812305246 cites W1937125644 @default.
• W1812305246 cites W1965341361 @default.
• W1812305246 cites W1968307591 @default.
• W1812305246 cites W1969787322 @default.
• W1812305246 cites W1969875009 @default.
• W1812305246 cites W1972306593 @default.
• W1812305246 cites W1973026261 @default.
• W1812305246 cites W1976768511 @default.
• W1812305246 cites W1979452848 @default.
• W1812305246 cites W1980809056 @default.
• W1812305246 cites W1981026976 @default.
• W1812305246 cites W1983880428 @default.
• W1812305246 cites W1984637746 @default.
• W1812305246 cites W1987184081 @default.
• W1812305246 cites W1989790607 @default.
• W1812305246 cites W1991802764 @default.
• W1812305246 cites W1995395951 @default.
• W1812305246 cites W1996014846 @default.
• W1812305246 cites W1998601670 @default.
• W1812305246 cites W2004587520 @default.
• W1812305246 cites W2004641590 @default.
• W1812305246 cites W2005941170 @default.
• W1812305246 cites W2006343862 @default.
• W1812305246 cites W2006395229 @default.
• W1812305246 cites W2009810652 @default.
• W1812305246 cites W2010039350 @default.
• W1812305246 cites W2010275458 @default.
• W1812305246 cites W2011007192 @default.
• W1812305246 cites W2013289425 @default.
• W1812305246 cites W2014128983 @default.
• W1812305246 cites W2014718897 @default.
• W1812305246 cites W2015449706 @default.
• W1812305246 cites W2019331917 @default.
• W1812305246 cites W2020224644 @default.
• W1812305246 cites W2023601336 @default.
• W1812305246 cites W2024029105 @default.
• W1812305246 cites W2026324275 @default.
• W1812305246 cites W2026596459 @default.
• W1812305246 cites W2033645959 @default.
• W1812305246 cites W2034285706 @default.
• W1812305246 cites W2034875698 @default.
• W1812305246 cites W2034942862 @default.
• W1812305246 cites W2035210283 @default.
• W1812305246 cites W2036463999 @default.
• W1812305246 cites W2040375372 @default.
• W1812305246 cites W2041626845 @default.
• W1812305246 cites W2042288802 @default.
• W1812305246 cites W2043017963 @default.
• W1812305246 cites W2043244700 @default.
• W1812305246 cites W2043666025 @default.
• W1812305246 cites W2044124936 @default.
• W1812305246 cites W2045601665 @default.
• W1812305246 cites W2047197858 @default.
• W1812305246 cites W2047802387 @default.
• W1812305246 cites W2054367542 @default.
• W1812305246 cites W2054862899 @default.
• W1812305246 cites W2055053622 @default.
• W1812305246 cites W2056279562 @default.
• W1812305246 cites W2056950778 @default.
• W1812305246 cites W2057282881 @default.
• W1812305246 cites W2061606914 @default.
• W1812305246 cites W2061728413 @default.
• W1812305246 cites W2064808544 @default.
• W1812305246 cites W2066452478 @default.
• W1812305246 cites W2067285942 @default.
• W1812305246 cites W2067537975 @default.
• W1812305246 cites W2069708996 @default.
• W1812305246 cites W2073586252 @default.
• W1812305246 cites W2073900830 @default.
• W1812305246 cites W2077335123 @default.
• W1812305246 cites W2077406052 @default.
• W1812305246 cites W2083210511 @default.
• W1812305246 cites W2083954189 @default.
• W1812305246 cites W2086554538 @default.
• W1812305246 cites W2087398582 @default.
• W1812305246 cites W2092115048 @default.
• W1812305246 cites W2092322277 @default.
• W1812305246 cites W2092489392 @default.
• W1812305246 cites W2093491339 @default.
• W1812305246 cites W2094331225 @default.
• W1812305246 cites W2094561245 @default.
• W1812305246 cites W2094821232 @default.
• W1812305246 cites W2095038217 @default.
• W1812305246 cites W2096020759 @default.

• next