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- W1812788896 abstract "To investigate the role of oxidant/antioxidant status and protein oxidation in the development of age-related macular degeneration.The activities of serum superoxide dismutase and glutathione peroxidase and the levels of serum malondialdehyde, advanced oxidation protein products, glutathione and vitamin C were measured in 25 patients with age-related macular degeneration and 25 control subjects without age-related macular degeneration.The malondialdehyde and advanced oxidation protein product levels in the serum were significantly higher in the age-related macular degeneration patient group than in the control group (p<0.05). The superoxide dismutase activity in the serum was significantly lower in the age-related macular degeneration patient group than in the control group (p<0.05). The levels of vitamin C and glutathione and the activity of glutathione peroxidase in the serum were unchanged between groups (p>0.05).The results of the present study suggest that decreased effectiveness of the antioxidant defense system and increased oxidative stress may play a role in the pathogenesis of age-related macular degeneration." @default.
- W1812788896 created "2016-06-24" @default.
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- W1812788896 date "2011-01-01" @default.
- W1812788896 modified "2023-09-29" @default.
- W1812788896 title "The role of oxidative stress and antioxidants in the pathogenesis of age-related macular degeneration." @default.
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- W1812788896 doi "https://doi.org/10.1590/s1807-59322011000500006" @default.
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