FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1813928154> ?p ?o ?g. }

• W1813928154 endingPage "144" @default.
• W1813928154 startingPage "137" @default.
• W1813928154 abstract "Background and Objectives Alcohol abuse complicates treatment of HIV disease and is linked to poor outcomes. Alcohol pharmacotherapies, including disulfiram (DIS), are infrequently utilized in co‐occurring HIV and alcohol use disorders possibly related to concerns about drug interactions between antiretroviral (ARV) medications and DIS. Method This pharmacokinetics study ( n = 40) examined the effect of DIS on efavirenz (EFV), ritonavir (RTV), or atazanavir (ATV) and the effect of these ARV medications on DIS metabolism and aldehyde dehydrogenase (ALDH) activity which mediates the DIS‐alcohol reaction. Results EFV administration was associated with decreased S‐Methyl‐ N ‐ N ‐diethylthiocarbamate (DIS carbamate), a metabolite of DIS ( p = .001) and a precursor to the metabolite responsible for ALDH inhibition, S‐methyl‐ N , N ‐diethylthiolcarbamate sulfoxide (DETC–MeSO). EFV was associated with increased DIS inhibition of ALDH activity relative to DIS alone administration possibly as a result of EFV‐associated induction of CYP 3A4 which metabolizes the carbamate to DETC–MeSO (which inhibits ALDH). Conversely, ATV co‐administration reduced the effect of DIS on ALDH activity possibly as a result of ATV inhibition of CYP 3A4. DIS administration had no significant effect on any ARV studied. Discussion/Conclusions ATV may render DIS ineffective in treatment of alcoholism. Future Directions DIS is infrequently utilized in HIV‐infected individuals due to concerns about adverse interactions and side effects. Findings from this study indicate that, with ongoing clinical monitoring, DIS should be reconsidered given its potential efficacy for alcohol and potentially, cocaine use disorders, that may occur in this population. (Am J Addict 2014;23:137–144)" @default.
• W1813928154 created "2016-06-24" @default.
• W1813928154 creator A5014397177 @default.
• W1813928154 creator A5016369714 @default.
• W1813928154 creator A5034738462 @default.
• W1813928154 creator A5037196439 @default.
• W1813928154 creator A5048499160 @default.
• W1813928154 creator A5055908944 @default.
• W1813928154 creator A5062818118 @default.
• W1813928154 creator A5065404552 @default.
• W1813928154 creator A5072635409 @default.
• W1813928154 creator A5075585167 @default.
• W1813928154 date "2013-10-11" @default.
• W1813928154 modified "2023-10-02" @default.
• W1813928154 title "Interaction of disulfiram with antiretroviral medications: Efavirenz increases while atazanavir decreases disulfiram effect on enzymes of alcohol metabolism" @default.
• W1813928154 cites W106587884 @default.
• W1813928154 cites W1963791120 @default.
• W1813928154 cites W2005996119 @default.
• W1813928154 cites W2006412927 @default.
• W1813928154 cites W2019709536 @default.
• W1813928154 cites W2025369226 @default.
• W1813928154 cites W2032456416 @default.
• W1813928154 cites W2040153644 @default.
• W1813928154 cites W2069068041 @default.
• W1813928154 cites W2071598538 @default.
• W1813928154 cites W2076884514 @default.
• W1813928154 cites W2084124490 @default.
• W1813928154 cites W2087860458 @default.
• W1813928154 cites W2089374096 @default.
• W1813928154 cites W2092250940 @default.
• W1813928154 cites W2093307568 @default.
• W1813928154 cites W2094335914 @default.
• W1813928154 cites W2095231520 @default.
• W1813928154 cites W2097656057 @default.
• W1813928154 cites W2100414335 @default.
• W1813928154 cites W2113993321 @default.
• W1813928154 cites W2130069006 @default.
• W1813928154 cites W2155020495 @default.
• W1813928154 cites W2156122963 @default.
• W1813928154 cites W2318335207 @default.
• W1813928154 doi "https://doi.org/10.1111/j.1521-0391.2013.12081.x" @default.
• W1813928154 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3984379" @default.
• W1813928154 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24118434" @default.
• W1813928154 hasPublicationYear "2013" @default.
• W1813928154 type Work @default.
• W1813928154 sameAs 1813928154 @default.
• W1813928154 citedByCount "14" @default.
• W1813928154 countsByYear W18139281542014 @default.
• W1813928154 countsByYear W18139281542015 @default.
• W1813928154 countsByYear W18139281542016 @default.
• W1813928154 countsByYear W18139281542017 @default.
• W1813928154 countsByYear W18139281542018 @default.
• W1813928154 countsByYear W18139281542020 @default.
• W1813928154 countsByYear W18139281542021 @default.
• W1813928154 countsByYear W18139281542022 @default.
• W1813928154 countsByYear W18139281542023 @default.
• W1813928154 crossrefType "journal-article" @default.
• W1813928154 hasAuthorship W1813928154A5014397177 @default.
• W1813928154 hasAuthorship W1813928154A5016369714 @default.
• W1813928154 hasAuthorship W1813928154A5034738462 @default.
• W1813928154 hasAuthorship W1813928154A5037196439 @default.
• W1813928154 hasAuthorship W1813928154A5048499160 @default.
• W1813928154 hasAuthorship W1813928154A5055908944 @default.
• W1813928154 hasAuthorship W1813928154A5062818118 @default.
• W1813928154 hasAuthorship W1813928154A5065404552 @default.
• W1813928154 hasAuthorship W1813928154A5072635409 @default.
• W1813928154 hasAuthorship W1813928154A5075585167 @default.
• W1813928154 hasBestOaLocation W18139281542 @default.
• W1813928154 hasConcept C112705442 @default.
• W1813928154 hasConcept C126322002 @default.
• W1813928154 hasConcept C142462285 @default.
• W1813928154 hasConcept C181199279 @default.
• W1813928154 hasConcept C185592680 @default.
• W1813928154 hasConcept C203014093 @default.
• W1813928154 hasConcept C25747580 @default.
• W1813928154 hasConcept C2777477808 @default.
• W1813928154 hasConcept C2778414717 @default.
• W1813928154 hasConcept C2778523461 @default.
• W1813928154 hasConcept C2779298103 @default.
• W1813928154 hasConcept C2780035454 @default.
• W1813928154 hasConcept C2781066024 @default.
• W1813928154 hasConcept C2781432083 @default.
• W1813928154 hasConcept C2908647359 @default.
• W1813928154 hasConcept C2993143319 @default.
• W1813928154 hasConcept C3013748606 @default.
• W1813928154 hasConcept C55493867 @default.
• W1813928154 hasConcept C71924100 @default.
• W1813928154 hasConcept C98274493 @default.
• W1813928154 hasConcept C99454951 @default.
• W1813928154 hasConceptScore W1813928154C112705442 @default.
• W1813928154 hasConceptScore W1813928154C126322002 @default.
• W1813928154 hasConceptScore W1813928154C142462285 @default.
• W1813928154 hasConceptScore W1813928154C181199279 @default.
• W1813928154 hasConceptScore W1813928154C185592680 @default.
• W1813928154 hasConceptScore W1813928154C203014093 @default.
• W1813928154 hasConceptScore W1813928154C25747580 @default.
• W1813928154 hasConceptScore W1813928154C2777477808 @default.
• W1813928154 hasConceptScore W1813928154C2778414717 @default.

• next