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- W1814262012 abstract "The quote what does not kill you makes you stronger perfectly describes the preconditioning phenomenon - a paradigm that affords robust brain tolerance in the face of neurodegenerative insults. Over the last few decades, many attempts have been made to identify the molecular mechanisms involved in preconditioning-induced protective responses, and recent data suggests that many of these mechanisms converge on the mitochondria, positing mitochondria as master regulators of preconditioning-triggered endogenous neuroprotection. In this review, we critically discuss evidence for the involvement of mitochondria within the preconditioning paradigm. We will highlight the crucial targets and mediators by which mitochondria are integrated into neuroprotective signaling pathways that underlie preconditioning, putting focus on mitochondrial respiratory chain and mitochondrial reactive oxygen species, mitochondrial ATP-sensitive potassium channels, mitochondrial permeability transition pore, uncoupling proteins, and mitochondrial antioxidant enzyme manganese superoxide dismutase. We also discuss the role of mitochondria in the induction of hypoxia-inducible factor-1, a transcription factor engaged in preconditioning-mediated neuroprotective effects. The identification of intrinsic mitochondrial mechanisms involved in preconditioning will provide new insights which can be translated into potential pharmacological interventions aimed at counteracting neurodegeneration." @default.
- W1814262012 created "2016-06-24" @default.
- W1814262012 creator A5021420538 @default.
- W1814262012 creator A5053059798 @default.
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- W1814262012 creator A5075477128 @default.
- W1814262012 creator A5076718299 @default.
- W1814262012 date "2010-06-03" @default.
- W1814262012 modified "2023-10-11" @default.
- W1814262012 title "Mitochondria: The Missing Link Between Preconditioning and Neuroprotection" @default.
- W1814262012 cites W1485468448 @default.
- W1814262012 cites W1500435375 @default.
- W1814262012 cites W1519302095 @default.
- W1814262012 cites W1547863599 @default.
- W1814262012 cites W1551955865 @default.
- W1814262012 cites W1554372630 @default.
- W1814262012 cites W1575495254 @default.
- W1814262012 cites W1635047156 @default.
- W1814262012 cites W1745469069 @default.
- W1814262012 cites W1745634660 @default.
- W1814262012 cites W193763600 @default.
- W1814262012 cites W1965724936 @default.
- W1814262012 cites W1968257316 @default.
- W1814262012 cites W1972656635 @default.
- W1814262012 cites W1977309424 @default.
- W1814262012 cites W1977524267 @default.
- W1814262012 cites W1982029249 @default.
- W1814262012 cites W1982281065 @default.
- W1814262012 cites W1982948052 @default.
- W1814262012 cites W1985586004 @default.
- W1814262012 cites W1986124091 @default.
- W1814262012 cites W1986326459 @default.
- W1814262012 cites W1986568749 @default.
- W1814262012 cites W1988522729 @default.
- W1814262012 cites W1988567967 @default.
- W1814262012 cites W1989130739 @default.
- W1814262012 cites W1990705161 @default.
- W1814262012 cites W1992678387 @default.
- W1814262012 cites W1998665484 @default.
- W1814262012 cites W1999142774 @default.
- W1814262012 cites W2000342449 @default.
- W1814262012 cites W2005008995 @default.
- W1814262012 cites W2008748100 @default.
- W1814262012 cites W2009653945 @default.
- W1814262012 cites W2009812062 @default.
- W1814262012 cites W2009869655 @default.
- W1814262012 cites W2010179451 @default.
- W1814262012 cites W2013747528 @default.
- W1814262012 cites W2016243384 @default.
- W1814262012 cites W2018504915 @default.
- W1814262012 cites W2020498032 @default.
- W1814262012 cites W2024267786 @default.
- W1814262012 cites W2025333162 @default.
- W1814262012 cites W2025446835 @default.
- W1814262012 cites W2026180855 @default.
- W1814262012 cites W2026635128 @default.
- W1814262012 cites W2027052432 @default.
- W1814262012 cites W2028132430 @default.
- W1814262012 cites W2029077404 @default.
- W1814262012 cites W2033234217 @default.
- W1814262012 cites W2033962191 @default.
- W1814262012 cites W2034799298 @default.
- W1814262012 cites W2035333205 @default.
- W1814262012 cites W2037943457 @default.
- W1814262012 cites W2038707186 @default.
- W1814262012 cites W2039054455 @default.
- W1814262012 cites W2044773612 @default.
- W1814262012 cites W2045201746 @default.
- W1814262012 cites W2045797497 @default.
- W1814262012 cites W2048221764 @default.
- W1814262012 cites W2053624576 @default.
- W1814262012 cites W2053879170 @default.
- W1814262012 cites W2057628589 @default.
- W1814262012 cites W2058121143 @default.
- W1814262012 cites W2059159853 @default.
- W1814262012 cites W2060317914 @default.
- W1814262012 cites W2063175209 @default.
- W1814262012 cites W2065099508 @default.
- W1814262012 cites W2067543666 @default.
- W1814262012 cites W2068118359 @default.
- W1814262012 cites W2069482140 @default.
- W1814262012 cites W2073614986 @default.
- W1814262012 cites W2078107116 @default.
- W1814262012 cites W2079781432 @default.
- W1814262012 cites W2080027027 @default.
- W1814262012 cites W2080218239 @default.
- W1814262012 cites W2080610618 @default.
- W1814262012 cites W2082340869 @default.
- W1814262012 cites W2082425573 @default.
- W1814262012 cites W2082782176 @default.
- W1814262012 cites W2084724753 @default.
- W1814262012 cites W2085470258 @default.
- W1814262012 cites W2088394572 @default.
- W1814262012 cites W2088629175 @default.
- W1814262012 cites W2092800106 @default.
- W1814262012 cites W2094172197 @default.
- W1814262012 cites W2094796288 @default.