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- W181431488 abstract "Over the past ten years, anticytokine therapies for the treatment of septic shock, adult respiratory distress syndrome (ARDS) and systemic inflammatory response syndrome (SIRS) have progressed from the laboratory to the clinic. It is now generally accepted that overproduction of several classes of proteins produced by inflammatory cells, termed pro-inflammatory cytokines, contribute to the pathological consequences of septic shock [1, 2]. Neutralizing an exaggerated endogenous tumor necrosis factor α (TNFα) response with anti-TNFα antibodies [3, 4], soluble TNF receptor immunadhesins [5, 6], or downregulating TNFα production with interleukin-10 (IL-10) pretreatment [7, 8] confers survival to otherwise lethal endotoxemia. Presently, clinical trials are underway with monoclonal antibodies and immunadhesins directed against TNFα in patients with sepsis syndrome [9]. Similarly, efforts to block an exaggerated interleukin-1 (IL-1) production, primarily with the use of IL-1 receptor antagonist (IL-1ra), have shown variable results in preclinical studies [10, 11] and early clinical trials [12]." @default.
- W181431488 created "2016-06-24" @default.
- W181431488 creator A5031094605 @default.
- W181431488 date "1999-01-01" @default.
- W181431488 modified "2023-09-24" @default.
- W181431488 title "Gene therapy — an alternative approach for anti-cytokine therapies" @default.
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- W181431488 doi "https://doi.org/10.1007/978-3-0348-8755-7_18" @default.
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