FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W18149726> ?p ?o ?g. }

• W18149726 endingPage "401" @default.
• W18149726 startingPage "389" @default.
• W18149726 abstract "The mechanisms of cell signaling and altered gene expression by asbestos, a potent inflammatory, fibrogenic, and carcinogenic agent, are unclear. Activation of the transcription factor, nuclear factor (NF)-kappa B, is critical in up-regulating the expression of many genes linked to inflammation and proliferation. Inhalation models of crocidolite- and chrysotile-induced inflammation and asbestosis were used to study the localization of p65, a protein subunit of the NF-kappa B transcription factor, in sham control rats and those exposed to asbestos. In addition, we investigated, using electrophoretic mobility shift analysis, whether in vitro exposure of rat lung epithelial cells and rat pleural mesothelial cells to asbestos increased binding of nuclear proteins, including p65, to the NF-kappa B DNA response element. Furthermore, translocation of p65 into the nucleus was determined by confocal microscopy. In comparison with sham animals, striking increases in p65 immunofluorescence were observed in airway epithelial cells of rats at 5 days after inhalation of asbestos. These increases were diminished by 20 days, the time period necessary for development of fibrotic lesions. In contrast, although inter-animal variability was observed, immunoreactivity for p65 was more dramatic in the interstitial compartment of asbestos-exposed rat lungs at both 5 and 20 days. Changes in p65 expression in pleural mesothelial cells exposed to asbestos in inhalation experiments were unremarkable. Exposure to asbestos also caused significant increases in nuclear protein complexes that bind the NF-kappa B consensus DNA sequence in both rat lung epithelial and rat pleural mesothelial cells. Using confocal microscopy, we observed partial nuclear translocation of p65 in rat pleural mesothelial cells exposed to asbestos. This partial response contrasted with the effects of lipopolysaccharide, which caused rapid and complete translocation of p65 from cytoplasm to nucleus. Our studies are the first to show the presence of the NF-kappa B system in lung tissue and evidence of activation in vitro and in vivo after exposure to a potent inflammatory, fibrinogenic, and carcinogenic environmental agent." @default.
• W18149726 created "2016-06-24" @default.
• W18149726 creator A5040898114 @default.
• W18149726 creator A5041655739 @default.
• W18149726 creator A5041802127 @default.
• W18149726 creator A5059835174 @default.
• W18149726 creator A5068060145 @default.
• W18149726 creator A5071370487 @default.
• W18149726 creator A5087444131 @default.
• W18149726 date "1997-08-01" @default.
• W18149726 modified "2023-09-23" @default.
• W18149726 title "Asbestos causes translocation of p65 protein and increases NF-kappa B DNA binding activity in rat lung epithelial and pleural mesothelial cells." @default.
• W18149726 cites W104947385 @default.
• W18149726 cites W1492606093 @default.
• W18149726 cites W1543945339 @default.
• W18149726 cites W1577403013 @default.
• W18149726 cites W1591881963 @default.
• W18149726 cites W1603650405 @default.
• W18149726 cites W1769783081 @default.
• W18149726 cites W1808872972 @default.
• W18149726 cites W1825540737 @default.
• W18149726 cites W1825703274 @default.
• W18149726 cites W1827829058 @default.
• W18149726 cites W1888783223 @default.
• W18149726 cites W1904739092 @default.
• W18149726 cites W1923921388 @default.
• W18149726 cites W1964218617 @default.
• W18149726 cites W1967116249 @default.
• W18149726 cites W1968140100 @default.
• W18149726 cites W1981488919 @default.
• W18149726 cites W1981583867 @default.
• W18149726 cites W1987767047 @default.
• W18149726 cites W1994518218 @default.
• W18149726 cites W1999429256 @default.
• W18149726 cites W2007166597 @default.
• W18149726 cites W2011952213 @default.
• W18149726 cites W2012323141 @default.
• W18149726 cites W2012744796 @default.
• W18149726 cites W2023895668 @default.
• W18149726 cites W2032824681 @default.
• W18149726 cites W2037915962 @default.
• W18149726 cites W2038132277 @default.
• W18149726 cites W2044165147 @default.
• W18149726 cites W2044167464 @default.
• W18149726 cites W2047770663 @default.
• W18149726 cites W2054487299 @default.
• W18149726 cites W2056186925 @default.
• W18149726 cites W2057737390 @default.
• W18149726 cites W2071167807 @default.
• W18149726 cites W2072552734 @default.
• W18149726 cites W2073032567 @default.
• W18149726 cites W2082575834 @default.
• W18149726 cites W2087244641 @default.
• W18149726 cites W2089478514 @default.
• W18149726 cites W2101637225 @default.
• W18149726 cites W2101759139 @default.
• W18149726 cites W2105599130 @default.
• W18149726 cites W2115827568 @default.
• W18149726 cites W2132023106 @default.
• W18149726 cites W2139319526 @default.
• W18149726 cites W2155516654 @default.
• W18149726 cites W2164983049 @default.
• W18149726 cites W2255582868 @default.
• W18149726 cites W303649752 @default.
• W18149726 cites W77653517 @default.
• W18149726 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1858001" @default.
• W18149726 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9250152" @default.
• W18149726 hasPublicationYear "1997" @default.
• W18149726 type Work @default.
• W18149726 sameAs 18149726 @default.
• W18149726 citedByCount "25" @default.
• W18149726 countsByYear W181497262012 @default.
• W18149726 countsByYear W181497262015 @default.
• W18149726 countsByYear W181497262017 @default.
• W18149726 countsByYear W181497262022 @default.
• W18149726 crossrefType "journal-article" @default.
• W18149726 hasAuthorship W18149726A5040898114 @default.
• W18149726 hasAuthorship W18149726A5041655739 @default.
• W18149726 hasAuthorship W18149726A5041802127 @default.
• W18149726 hasAuthorship W18149726A5059835174 @default.
• W18149726 hasAuthorship W18149726A5068060145 @default.
• W18149726 hasAuthorship W18149726A5071370487 @default.
• W18149726 hasAuthorship W18149726A5087444131 @default.
• W18149726 hasConcept C104317684 @default.
• W18149726 hasConcept C111963520 @default.
• W18149726 hasConcept C123298856 @default.
• W18149726 hasConcept C142724271 @default.
• W18149726 hasConcept C153911025 @default.
• W18149726 hasConcept C185592680 @default.
• W18149726 hasConcept C191897082 @default.
• W18149726 hasConcept C192562407 @default.
• W18149726 hasConcept C203014093 @default.
• W18149726 hasConcept C2776256026 @default.
• W18149726 hasConcept C2776914184 @default.
• W18149726 hasConcept C2777730290 @default.
• W18149726 hasConcept C2779747549 @default.
• W18149726 hasConcept C2909640154 @default.
• W18149726 hasConcept C510490043 @default.

• next