Matches in SemOpenAlex for { <https://semopenalex.org/work/W1815204764> ?p ?o ?g. }
- W1815204764 endingPage "550" @default.
- W1815204764 startingPage "541" @default.
- W1815204764 abstract "Previous reports have suggested an association between elevated fibrinogen and CAD. Few studies have so far investigated the impact of diabetes on fibrinogen levels and its association with coronary artery disease (CAD) and platelet reactivity in diabetic patients that are therefore the aims of the current study.We measured fibrinogen in 3280 consecutive patients undergoing coronary angiography. Samples were collected at admission for fibrinogen levels assessment. Coronary disease was defined for at least 1 vessel stenosis >50% as evaluated by QCA.Diabetes was observed in 1201 out of 3280 patients. Diabetic patients were older with more hypercholesterolemia, hypertension, higher BMI, more renal failure, previous MI or coronary revascularization (p<0.001, respectively) and smoking (p=0.001). Diabetic patients were more often on ACE-inhibitors, ARBs, b-blockers, calcium-antagonists, diuretics, statins (p<0.001, respectively), and ASA (p=0.004). Diabetic patients displayed higher glycaemia and HbA1c (p<0.001), higher creatinine and triglycerides (p<0.001) but lower total and HDL cholesterol (p<0.001) and haemoglobin (p<0.001). Diabetic patients had higher fibrinogen levels (p=0.003), however neither diabetes nor glucose homeostasis parameters resulted as independent predictors of hyperfibrinogenemia. Furthermore, among diabetic patients, higher fibrinogen levels did not affect platelet reactivity and were not associated with the prevalence of CAD (adjusted OR[95%CI]=0.99 [0.82-1.19], p=0.9). Similar results were found for severe CAD (adjusted OR[95%CI]=0.94 [0.82-1.08], p=0.40).Our study showed that diabetes and glycaemic control are not independent predictors of hyperfibrinogenemia. Among diabetic patients, elevated fibrinogen is not associated with platelet reactivity and the prevalence and extent of CAD." @default.
- W1815204764 created "2016-06-24" @default.
- W1815204764 creator A5000400608 @default.
- W1815204764 creator A5000948027 @default.
- W1815204764 creator A5013110426 @default.
- W1815204764 creator A5015479782 @default.
- W1815204764 creator A5019524070 @default.
- W1815204764 creator A5024732332 @default.
- W1815204764 creator A5044500702 @default.
- W1815204764 creator A5064670948 @default.
- W1815204764 creator A5068649190 @default.
- W1815204764 creator A5074623692 @default.
- W1815204764 date "2015-09-01" @default.
- W1815204764 modified "2023-09-26" @default.
- W1815204764 title "Impact of diabetes on fibrinogen levels and its relationship with platelet reactivity and coronary artery disease: A single-centre study" @default.
- W1815204764 cites W1581737302 @default.
- W1815204764 cites W1932331501 @default.
- W1815204764 cites W1978049330 @default.
- W1815204764 cites W1979949191 @default.
- W1815204764 cites W1989944723 @default.
- W1815204764 cites W1992742717 @default.
- W1815204764 cites W1994281012 @default.
- W1815204764 cites W1994324711 @default.
- W1815204764 cites W2008279324 @default.
- W1815204764 cites W2010545674 @default.
- W1815204764 cites W2011498879 @default.
- W1815204764 cites W2019631323 @default.
- W1815204764 cites W2022928811 @default.
- W1815204764 cites W2023266656 @default.
- W1815204764 cites W2025001402 @default.
- W1815204764 cites W2028520543 @default.
- W1815204764 cites W2032167693 @default.
- W1815204764 cites W2041351616 @default.
- W1815204764 cites W2057651652 @default.
- W1815204764 cites W2058812862 @default.
- W1815204764 cites W2059627219 @default.
- W1815204764 cites W2061836528 @default.
- W1815204764 cites W2064195086 @default.
- W1815204764 cites W2072428328 @default.
- W1815204764 cites W2078903829 @default.
- W1815204764 cites W2081143213 @default.
- W1815204764 cites W2085586529 @default.
- W1815204764 cites W2087387326 @default.
- W1815204764 cites W2087967133 @default.
- W1815204764 cites W2101965930 @default.
- W1815204764 cites W2108122635 @default.
- W1815204764 cites W2110119548 @default.
- W1815204764 cites W2119311183 @default.
- W1815204764 cites W2131720908 @default.
- W1815204764 cites W2136094514 @default.
- W1815204764 cites W2149916913 @default.
- W1815204764 cites W2151107953 @default.
- W1815204764 cites W2152804512 @default.
- W1815204764 cites W2155002935 @default.
- W1815204764 cites W2158383046 @default.
- W1815204764 cites W2158977363 @default.
- W1815204764 cites W2167239650 @default.
- W1815204764 cites W2170422070 @default.
- W1815204764 cites W2331473921 @default.
- W1815204764 cites W2411464566 @default.
- W1815204764 cites W2412039175 @default.
- W1815204764 cites W2443473659 @default.
- W1815204764 cites W2913967451 @default.
- W1815204764 cites W43218661 @default.
- W1815204764 doi "https://doi.org/10.1016/j.diabres.2015.05.038" @default.
- W1815204764 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26163440" @default.
- W1815204764 hasPublicationYear "2015" @default.
- W1815204764 type Work @default.
- W1815204764 sameAs 1815204764 @default.
- W1815204764 citedByCount "4" @default.
- W1815204764 countsByYear W18152047642016 @default.
- W1815204764 countsByYear W18152047642018 @default.
- W1815204764 countsByYear W18152047642019 @default.
- W1815204764 countsByYear W18152047642020 @default.
- W1815204764 crossrefType "journal-article" @default.
- W1815204764 hasAuthorship W1815204764A5000400608 @default.
- W1815204764 hasAuthorship W1815204764A5000948027 @default.
- W1815204764 hasAuthorship W1815204764A5013110426 @default.
- W1815204764 hasAuthorship W1815204764A5015479782 @default.
- W1815204764 hasAuthorship W1815204764A5019524070 @default.
- W1815204764 hasAuthorship W1815204764A5024732332 @default.
- W1815204764 hasAuthorship W1815204764A5044500702 @default.
- W1815204764 hasAuthorship W1815204764A5064670948 @default.
- W1815204764 hasAuthorship W1815204764A5068649190 @default.
- W1815204764 hasAuthorship W1815204764A5074623692 @default.
- W1815204764 hasConcept C126322002 @default.
- W1815204764 hasConcept C134018914 @default.
- W1815204764 hasConcept C164705383 @default.
- W1815204764 hasConcept C2778213512 @default.
- W1815204764 hasConcept C2779036427 @default.
- W1815204764 hasConcept C2780306776 @default.
- W1815204764 hasConcept C555293320 @default.
- W1815204764 hasConcept C71924100 @default.
- W1815204764 hasConceptScore W1815204764C126322002 @default.
- W1815204764 hasConceptScore W1815204764C134018914 @default.
- W1815204764 hasConceptScore W1815204764C164705383 @default.
- W1815204764 hasConceptScore W1815204764C2778213512 @default.
- W1815204764 hasConceptScore W1815204764C2779036427 @default.