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- W1815285420 abstract "The purpose of this study was to investigate risk for neuroticism due to the joint action of low maternal care and compromised mesocorticolimbic ‘reward’ system function linked to a variable number tandem repeat (VNTR) in the dopamine 4 receptor gene (DRD4). Data were drawn from the Victorian Adolescent Health Cohort Study, a longitudinal study of the health and well‐being of 2,000 young Australians followed from adolescence to young adulthood across 8 waves from 14‐ to 28‐years. Genetic risk was defined by carriage of at least one copy of the 7‐repeat allele or derivative alleles 5, 6, and 8 (labeled 7R+). Neuroticism was assessed in adolescence and young adulthood. We observed an approximately fourfold increase in the odds of reporting neurotic symptoms in carriers of the 7R+ disposition who reported low maternal care compared with non‐carriers who reported high maternal care. The percentage of risk attributable to mechanisms in which both factors played a role was 35%. Findings are discussed in terms of implications for prevention." @default.
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- W1815285420 date "2011-03-01" @default.
- W1815285420 modified "2023-10-17" @default.
- W1815285420 title "Modeling gene‐environment interaction in longitudinal data: Risk for neuroticism due to interaction between maternal care and the Dopamine 4 Receptor gene (DRD4)" @default.
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- W1815285420 doi "https://doi.org/10.1111/j.1742-9536.2011.00003.x" @default.
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