Matches in SemOpenAlex for { <https://semopenalex.org/work/W1815650112> ?p ?o ?g. }
- W1815650112 endingPage "4870" @default.
- W1815650112 startingPage "4864" @default.
- W1815650112 abstract "AMPA receptors expressed at auditory nerve synapses in the mammalian and avian cochlear nuclei display exceptionally rapid channel gating, an adaptation well suited for acoustic processing. We examined whether cellular interactions during development might determine the subunit composition of these receptors. After synapse formation in the avian nucleus magnocellularis (nMag) in vivo, the rate of receptor desensitization increased threefold, sensitivity to channel block by polyamines increased, and sensitivity to cyclothiazide, an inhibitor of desensitization, increased, indicating a reduction in glutamate receptor subunit 2 and of flip splice variants. This phenotypic switch was prevented, but not reversed, by isolating nMag neurons in a cell-culture environment. We propose that the switch in receptor kinetics is an outcome of cellular interactions during a critical period that result in the long-term determination of receptor phenotype." @default.
- W1815650112 created "2016-06-24" @default.
- W1815650112 creator A5027038334 @default.
- W1815650112 creator A5040263460 @default.
- W1815650112 date "2000-07-01" @default.
- W1815650112 modified "2023-10-18" @default.
- W1815650112 title "Long-Term Specification of AMPA Receptor Properties after Synapse Formation" @default.
- W1815650112 cites W1488984408 @default.
- W1815650112 cites W1511174464 @default.
- W1815650112 cites W1527250922 @default.
- W1815650112 cites W1540417297 @default.
- W1815650112 cites W1547595533 @default.
- W1815650112 cites W1548603509 @default.
- W1815650112 cites W1551088980 @default.
- W1815650112 cites W1587655960 @default.
- W1815650112 cites W1816101293 @default.
- W1815650112 cites W1842711843 @default.
- W1815650112 cites W1843466502 @default.
- W1815650112 cites W1940372664 @default.
- W1815650112 cites W1957270349 @default.
- W1815650112 cites W1963879245 @default.
- W1815650112 cites W1965273069 @default.
- W1815650112 cites W1965504075 @default.
- W1815650112 cites W1970953072 @default.
- W1815650112 cites W1980642537 @default.
- W1815650112 cites W1984259853 @default.
- W1815650112 cites W1986034290 @default.
- W1815650112 cites W2004429279 @default.
- W1815650112 cites W2007632540 @default.
- W1815650112 cites W2009011152 @default.
- W1815650112 cites W2020931572 @default.
- W1815650112 cites W2024421127 @default.
- W1815650112 cites W2025809696 @default.
- W1815650112 cites W2042906577 @default.
- W1815650112 cites W2048393820 @default.
- W1815650112 cites W2063987809 @default.
- W1815650112 cites W2064751454 @default.
- W1815650112 cites W2065169750 @default.
- W1815650112 cites W2067334833 @default.
- W1815650112 cites W2067847747 @default.
- W1815650112 cites W2071580220 @default.
- W1815650112 cites W2074361963 @default.
- W1815650112 cites W2074492501 @default.
- W1815650112 cites W2076171494 @default.
- W1815650112 cites W2076883859 @default.
- W1815650112 cites W2083045813 @default.
- W1815650112 cites W2089116626 @default.
- W1815650112 cites W2092845943 @default.
- W1815650112 cites W2099410255 @default.
- W1815650112 cites W2106415123 @default.
- W1815650112 cites W2110534885 @default.
- W1815650112 cites W2123918978 @default.
- W1815650112 cites W2147561535 @default.
- W1815650112 cites W2151444391 @default.
- W1815650112 cites W2160988290 @default.
- W1815650112 cites W2161729720 @default.
- W1815650112 cites W2163208697 @default.
- W1815650112 cites W2171370311 @default.
- W1815650112 cites W2302991284 @default.
- W1815650112 cites W4231950047 @default.
- W1815650112 cites W4238793555 @default.
- W1815650112 cites W4299125852 @default.
- W1815650112 cites W800904743 @default.
- W1815650112 doi "https://doi.org/10.1523/jneurosci.20-13-04864.2000" @default.
- W1815650112 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6772288" @default.
- W1815650112 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10864943" @default.
- W1815650112 hasPublicationYear "2000" @default.
- W1815650112 type Work @default.
- W1815650112 sameAs 1815650112 @default.
- W1815650112 citedByCount "70" @default.
- W1815650112 countsByYear W18156501122012 @default.
- W1815650112 countsByYear W18156501122013 @default.
- W1815650112 countsByYear W18156501122014 @default.
- W1815650112 countsByYear W18156501122015 @default.
- W1815650112 countsByYear W18156501122016 @default.
- W1815650112 countsByYear W18156501122018 @default.
- W1815650112 countsByYear W18156501122019 @default.
- W1815650112 countsByYear W18156501122020 @default.
- W1815650112 countsByYear W18156501122021 @default.
- W1815650112 countsByYear W18156501122023 @default.
- W1815650112 crossrefType "journal-article" @default.
- W1815650112 hasAuthorship W1815650112A5027038334 @default.
- W1815650112 hasAuthorship W1815650112A5040263460 @default.
- W1815650112 hasBestOaLocation W18156501121 @default.
- W1815650112 hasConcept C104292427 @default.
- W1815650112 hasConcept C104317684 @default.
- W1815650112 hasConcept C127445978 @default.
- W1815650112 hasConcept C154559735 @default.
- W1815650112 hasConcept C160268369 @default.
- W1815650112 hasConcept C169760540 @default.
- W1815650112 hasConcept C170493617 @default.
- W1815650112 hasConcept C185592680 @default.
- W1815650112 hasConcept C194544171 @default.
- W1815650112 hasConcept C2776104367 @default.
- W1815650112 hasConcept C2779779143 @default.
- W1815650112 hasConcept C55493867 @default.
- W1815650112 hasConcept C61174792 @default.
- W1815650112 hasConcept C86803240 @default.