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• W1815690010 abstract "Objectives. This open-label study assessed the efficacy and safety of exclusive night-time administration of transdermal rotigotine in patients with nocturnal and early morning PD symptoms. Methods. Patients with PD and nocturnal and early morning symptoms received transdermal rotigotine patches (2–16 mg/24 h) applied in the evening and removed in the morning for 3 months. Sleep disturbance was assessed with modified Parkinson’s Disease Sleep Scale (PDSS-2). Other outcomes included a pain visual analogue scale (VAS) and short-form Parkinson’s Disease Questionnaire (PDQ-8) for quality of life. Results. 74 patients completed treatment in this study. At the end of treatment, PDSS-2 total score had improved by mean 10.9 points from baseline ( p < 0.001). All three PDSS-2 domain scores (sleep disturbances, nocturnal motor symptoms, and nocturnal symptoms) were also significantly improved by 41%, 56%, and 48%, respectively ( p < 0.001). VAS-pain score decreased from 3.2 to 2.3 ( p < 0.001). PDQ-8 score decreased from 23.8 to 18.1 ( p < 0.001). The most frequently reported adverse events included nausea (9%), anxiety (4%), and dizziness (4%). Conclusions. Night-time administration of transdermal rotigotine is an effective and well tolerated treatment for nocturnal symptoms in patients with PD." @default.
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• W1815690010 date "2015-01-01" @default.
• W1815690010 modified "2023-10-08" @default.
• W1815690010 title "Effects of Night-Time Use of Rotigotine on Nocturnal Symptoms in Parkinson’s Disease" @default.
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• W1815690010 doi "https://doi.org/10.1155/2015/475630" @default.
• W1815690010 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4632005" @default.
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