FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1815698031> ?p ?o ?g. }

• W1815698031 endingPage "2899" @default.
• W1815698031 startingPage "2890" @default.
• W1815698031 abstract "Lower 25‐hydroxyvitamin D 2 /D 3 levels at melanoma diagnosis are associated with thicker primaries and poorer survival. We postulated that this might relate to the deleterious effect of systemic inflammation as 25‐hydroxyvitamin D 2 /D 3 levels are inversely associated with levels of C‐reactive protein. 2,182 participants in the Leeds Melanoma Cohort (median follow‐up 7.98 years) provided data on drug exposure, comorbidities and a serum 25‐hydroxyvitamin D 2 /D 3 level at recruitment. Factors reported to modify systemic inflammation (low vitamin D levels, high body mass index, use of aspirin or nonsteroidal anti‐inflammatory drugs or smoking were tested as predictors of microscopic ulceration (in which primary tumors are inflamed) and melanoma‐specific survival (MSS). Ulceration was independently associated with lower 25‐hydroxyvitamin D 2 /D 3 levels (odds ratio (OR) = 0.94 per 10 nmol/L, 95% CI 0.88–1.00, p = 0.05) and smoking at diagnosis (OR = 1.47, 95% CI 1.00–2.15, p = 0.04). In analyses adjusted for age and sex, a protective effect was seen of 25‐hydroxyvitamin D 2 /D 3 levels at diagnosis on melanoma death (OR = 0.89 per 10 nmol/L, 95% CI 0.83–0.95, p < 0.001) and smoking increased the risk of death (OR = 1.13 per 10 years, 95% CI 1.05–1.22, p = 0.001). In multivariable analyses (adjusted for tumor thickness) the associations with death from melanoma were low 25‐hydroxyvitamin D 2 /D 3 level at recruitment (<20 nmol/L vs . 20–60 nmol/L, hazard ratio (HR) = 1.52, 95% CI 0.97–2.40, p = 0.07) and smoking duration at diagnosis (HR = 1.11, 95% CI 1.03–1.20, p = 0.009). The study shows evidence that lower vitamin D levels and smoking are associated with ulceration of primary melanomas and poorer MSS. Further analyses are necessary to understand any biological mechanisms that underlie these findings." @default.
• W1815698031 created "2016-06-24" @default.
• W1815698031 creator A5020115168 @default.
• W1815698031 creator A5028536974 @default.
• W1815698031 creator A5044801113 @default.
• W1815698031 creator A5055535893 @default.
• W1815698031 creator A5057826438 @default.
• W1815698031 creator A5074307068 @default.
• W1815698031 creator A5077205401 @default.
• W1815698031 creator A5078369847 @default.
• W1815698031 creator A5083910611 @default.
• W1815698031 creator A5089040458 @default.
• W1815698031 date "2014-12-13" @default.
• W1815698031 modified "2023-10-14" @default.
• W1815698031 title "25‐Hydroxyvitamin D ₂ /D ₃ levels and factors associated with systemic inflammation and melanoma survival in the Leeds Melanoma Cohort" @default.
• W1815698031 cites W1506557546 @default.
• W1815698031 cites W1513833217 @default.
• W1815698031 cites W1968002935 @default.
• W1815698031 cites W1978860428 @default.
• W1815698031 cites W1981663682 @default.
• W1815698031 cites W1984959531 @default.
• W1815698031 cites W1991177531 @default.
• W1815698031 cites W1992904119 @default.
• W1815698031 cites W2002395040 @default.
• W1815698031 cites W2011572647 @default.
• W1815698031 cites W2017641946 @default.
• W1815698031 cites W2023997748 @default.
• W1815698031 cites W2024555963 @default.
• W1815698031 cites W2037280957 @default.
• W1815698031 cites W2038405099 @default.
• W1815698031 cites W2064512935 @default.
• W1815698031 cites W2068641046 @default.
• W1815698031 cites W2075552579 @default.
• W1815698031 cites W2080082173 @default.
• W1815698031 cites W2085956469 @default.
• W1815698031 cites W2090534878 @default.
• W1815698031 cites W2094354621 @default.
• W1815698031 cites W2105365180 @default.
• W1815698031 cites W2107072401 @default.
• W1815698031 cites W2113032639 @default.
• W1815698031 cites W2117692326 @default.
• W1815698031 cites W2118863192 @default.
• W1815698031 cites W2119754704 @default.
• W1815698031 cites W2121071739 @default.
• W1815698031 cites W2122672215 @default.
• W1815698031 cites W2123105952 @default.
• W1815698031 cites W2131147451 @default.
• W1815698031 cites W2135728814 @default.
• W1815698031 cites W2153814729 @default.
• W1815698031 cites W2160381920 @default.
• W1815698031 cites W2165788387 @default.
• W1815698031 cites W2169198054 @default.
• W1815698031 cites W2170121153 @default.
• W1815698031 cites W2171986743 @default.
• W1815698031 cites W2175210193 @default.
• W1815698031 doi "https://doi.org/10.1002/ijc.29334" @default.
• W1815698031 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4397121" @default.
• W1815698031 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25403087" @default.
• W1815698031 hasPublicationYear "2014" @default.
• W1815698031 type Work @default.
• W1815698031 sameAs 1815698031 @default.
• W1815698031 citedByCount "57" @default.
• W1815698031 countsByYear W18156980312015 @default.
• W1815698031 countsByYear W18156980312016 @default.
• W1815698031 countsByYear W18156980312017 @default.
• W1815698031 countsByYear W18156980312018 @default.
• W1815698031 countsByYear W18156980312019 @default.
• W1815698031 countsByYear W18156980312020 @default.
• W1815698031 countsByYear W18156980312021 @default.
• W1815698031 countsByYear W18156980312022 @default.
• W1815698031 countsByYear W18156980312023 @default.
• W1815698031 crossrefType "journal-article" @default.
• W1815698031 hasAuthorship W1815698031A5020115168 @default.
• W1815698031 hasAuthorship W1815698031A5028536974 @default.
• W1815698031 hasAuthorship W1815698031A5044801113 @default.
• W1815698031 hasAuthorship W1815698031A5055535893 @default.
• W1815698031 hasAuthorship W1815698031A5057826438 @default.
• W1815698031 hasAuthorship W1815698031A5074307068 @default.
• W1815698031 hasAuthorship W1815698031A5077205401 @default.
• W1815698031 hasAuthorship W1815698031A5078369847 @default.
• W1815698031 hasAuthorship W1815698031A5083910611 @default.
• W1815698031 hasAuthorship W1815698031A5089040458 @default.
• W1815698031 hasBestOaLocation W18156980311 @default.
• W1815698031 hasConcept C124490489 @default.
• W1815698031 hasConcept C126322002 @default.
• W1815698031 hasConcept C156957248 @default.
• W1815698031 hasConcept C2776914184 @default.
• W1815698031 hasConcept C2777628954 @default.
• W1815698031 hasConcept C2777658100 @default.
• W1815698031 hasConcept C2780221984 @default.
• W1815698031 hasConcept C502942594 @default.
• W1815698031 hasConcept C71924100 @default.
• W1815698031 hasConcept C72563966 @default.
• W1815698031 hasConcept C90924648 @default.
• W1815698031 hasConceptScore W1815698031C124490489 @default.
• W1815698031 hasConceptScore W1815698031C126322002 @default.
• W1815698031 hasConceptScore W1815698031C156957248 @default.
• W1815698031 hasConceptScore W1815698031C2776914184 @default.

• next