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- W181595663 abstract "Inosine-5′-monophosphate dehydrogenase (EC 1.1.1.205) catalyzes the formation of xanthosine-5′-monophosphate from inosine-5′-monophosphate (IMP). In the purine synthetic pathway, IMP dehydrogenase is the rate-limiting enzyme in the de novo synthesis of guanine nucleotides. Changes in IMP dehydrogenase activity have been implicated in the regulation of cell growth and differentiation (1). Inhibitor of this enzyme has been reported to inhibit cell growth and to induce cell differentiation in myeloid, monocytic, erythroid, or T-cell leukemia cell lines through a decline of intracellular GTP level (2–5). However, it has still not been clear how decreases in intracellular GTP levels induce differentiation. In parallel, protein kinase C (PKC) is a family of serine-threonine protein kinase that has been implicated as one of the prime regulatory enzyme that is activated in response to many external stimuli (6). Studies from a numerous number of laboratories have shown that PKC-mediated signal transduction pathway handles cell growth and differentiation. In this study, we investigate that reduction of intracellular GTP level promotes myeloid differentiation through PKC-β-mediated signal transduction pathway using a PKC-β deficient variant myeloid cell line." @default.
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- W181595663 date "1998-01-01" @default.
- W181595663 modified "2023-09-25" @default.
- W181595663 title "Low GTP Induces PKC-β-Dependent Myeloid Cell Differentiation" @default.
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- W181595663 doi "https://doi.org/10.1007/978-1-4615-5381-6_84" @default.
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