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• W1816103982 abstract "The distinction between metastatic breast carcinomas (BCs) and primary lung carcinomas (PLCs) can be difficult. This study tested the utility of trefoil factor 1 (TFF1) for this purpose and compared it with mammaglobin and GATA protein binding 3 (GATA-3).Tissue microarrays containing 365 BCs and 338 PLCs were stained with TFF1, mammaglobin, and GATA-3, and an H-score was calculated. Sensitivity, specificity, and accuracy were calculated, and logistical regression analysis was performed.Accuracy of correctly classifying the tumor type was 81.9%, 71.3%, and 64.0% for GATA-3, mammaglobin, and TFF1, respectively. Odds ratios for selecting BCs were 25.69, 93.15, and 4.17, respectively, with P values less than .001. With a single exception, the best immunopanel included GATA-3 and mammaglobin in all comparisons.TFF1 demonstrated breast specificity but was inferior to mammaglobin and GATA-3. Therefore, its routine clinical use may not be justified. TFF1 showed little benefit when added to an immunopanel." @default.
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• W1816103982 date "2015-09-01" @default.
• W1816103982 modified "2023-10-05" @default.
• W1816103982 title "Evaluating the Utility of Trefoil Factor 1 as a Mammary-Specific Immunostain Compared and in Conjunction With GATA-3 and Mammaglobin in the Distinction Between Carcinoma of Breast and Lung" @default.
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• W1816103982 doi "https://doi.org/10.1309/ajcpc7fa3ihypepf" @default.
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