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- W1816461957 endingPage "1943" @default.
- W1816461957 startingPage "1935" @default.
- W1816461957 abstract "Lenvatinib is an oral multitargeted tyrosine kinase inhibitor of VEGFR1,2,3,4, FGFR1,2,3,4, PDGFR-α as well as RET and KIT signaling network. Its activity against radioiodine-resistant differentiated thyroid cancer (DTC) has been recently demonstrated. Patients, who were given lenvatinib, showed significantly longer median progression free survival than placebo group, 18.3 vs 3.6 months, respectively. This review is focused on lenvatinib safety profile in patients treated due to DTC and medullary thyroid carcinoma. Among the most frequent lenvatinib-related adverse events (AEs) were hypertension, proteinuria, diarrhea, appetite decrease, weight loss, nausea and stomatitis. Although a lot of them were manageable, in 35-68% of patients dose reduction was required. Nevertheless, only 15% of subjects withdrew the drug due to its toxicity.published results of clinical trials phase II and III investigating both safety and efficacy of lenvatinib in thyroid cancer.Lenvatinib shows acceptable safety profile in patients with thyroid carcinoma. Treatment-related side effects are usually manageable by dose modifications or by concomitant non-pharmacological and pharmacological treatment. However, the early recognition of any potential drug toxicity is crucial to avoid serious complications as well as to keep a patient on drug as long as the treatment is beneficial." @default.
- W1816461957 created "2016-06-24" @default.
- W1816461957 creator A5003851108 @default.
- W1816461957 creator A5044375389 @default.
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- W1816461957 date "2015-10-20" @default.
- W1816461957 modified "2023-10-18" @default.
- W1816461957 title "Drug safety evaluation of lenvatinib for thyroid cancer" @default.
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- W1816461957 doi "https://doi.org/10.1517/14740338.2015.1102883" @default.
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