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- W1816471535 endingPage "12" @default.
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- W1816471535 abstract "Alternative splicing allows cells to expand the encoding potential of their genomes. In this elegant mechanism, a single gene can yield protein isoforms with even antagonistic functions depending on the cellular physiological context. Alterations in splicing regulatory factors activity in cancer cells, however, can generate an abnormal protein expression pattern that promotes growth, survival, and other processes, which are relevant to tumor biology. In this review, we discuss dysregulated alternative splicing events and regulatory factors that impact pathways related to cancer. The SR proteins and their regulatory kinases SRPKs and CLKs have been frequently found altered in tumors and are examined in more detail. Finally, perspectives that support splicing machinery as target for the development of novel anticancer therapies are discussed." @default.
- W1816471535 created "2016-06-24" @default.
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- W1816471535 creator A5090992573 @default.
- W1816471535 date "2015-01-01" @default.
- W1816471535 modified "2023-10-16" @default.
- W1816471535 title "Splicing Regulators and Their Roles in Cancer Biology and Therapy" @default.
- W1816471535 cites W1524688066 @default.
- W1816471535 cites W1531644439 @default.
- W1816471535 cites W1547004942 @default.
- W1816471535 cites W1768547176 @default.
- W1816471535 cites W1812729869 @default.
- W1816471535 cites W1920712310 @default.
- W1816471535 cites W1965619464 @default.
- W1816471535 cites W1966773848 @default.
- W1816471535 cites W1969431271 @default.
- W1816471535 cites W1970108031 @default.
- W1816471535 cites W1970578871 @default.
- W1816471535 cites W1972148963 @default.
- W1816471535 cites W1975151320 @default.
- W1816471535 cites W1976221241 @default.
- W1816471535 cites W1976226375 @default.
- W1816471535 cites W1978124146 @default.
- W1816471535 cites W1986639906 @default.
- W1816471535 cites W1987067331 @default.
- W1816471535 cites W1987450903 @default.
- W1816471535 cites W198776403 @default.
- W1816471535 cites W1989147967 @default.
- W1816471535 cites W1991142042 @default.
- W1816471535 cites W1992049575 @default.
- W1816471535 cites W1992332829 @default.
- W1816471535 cites W1993628564 @default.
- W1816471535 cites W1993899393 @default.
- W1816471535 cites W1995048208 @default.
- W1816471535 cites W1997500900 @default.
- W1816471535 cites W1997669303 @default.
- W1816471535 cites W1998107319 @default.
- W1816471535 cites W2000567082 @default.
- W1816471535 cites W2001327335 @default.
- W1816471535 cites W2007087942 @default.
- W1816471535 cites W2007501783 @default.
- W1816471535 cites W2008079379 @default.
- W1816471535 cites W2012166934 @default.
- W1816471535 cites W2021074776 @default.
- W1816471535 cites W2023002612 @default.
- W1816471535 cites W2026657651 @default.
- W1816471535 cites W2027701384 @default.
- W1816471535 cites W2027804420 @default.
- W1816471535 cites W2029964462 @default.
- W1816471535 cites W2030056549 @default.
- W1816471535 cites W2035242839 @default.
- W1816471535 cites W2036842663 @default.
- W1816471535 cites W2041864772 @default.
- W1816471535 cites W2042198997 @default.
- W1816471535 cites W2043157255 @default.
- W1816471535 cites W2049760326 @default.
- W1816471535 cites W2056378496 @default.
- W1816471535 cites W2057368600 @default.
- W1816471535 cites W2060138327 @default.
- W1816471535 cites W2062124626 @default.
- W1816471535 cites W2063106327 @default.
- W1816471535 cites W2063176993 @default.
- W1816471535 cites W2065970899 @default.
- W1816471535 cites W2068274700 @default.
- W1816471535 cites W2073013784 @default.
- W1816471535 cites W2073683821 @default.
- W1816471535 cites W2074084089 @default.
- W1816471535 cites W2077594389 @default.
- W1816471535 cites W2079650395 @default.
- W1816471535 cites W2081478041 @default.
- W1816471535 cites W2081604575 @default.
- W1816471535 cites W2082639157 @default.
- W1816471535 cites W2082834726 @default.
- W1816471535 cites W2083207235 @default.
- W1816471535 cites W2087646012 @default.
- W1816471535 cites W2089193902 @default.
- W1816471535 cites W2095715640 @default.
- W1816471535 cites W2096258050 @default.
- W1816471535 cites W2096592500 @default.
- W1816471535 cites W2098297062 @default.
- W1816471535 cites W2098824600 @default.
- W1816471535 cites W2101636442 @default.
- W1816471535 cites W2103440764 @default.
- W1816471535 cites W2103521510 @default.
- W1816471535 cites W2110538588 @default.
- W1816471535 cites W2112424582 @default.
- W1816471535 cites W2113516035 @default.
- W1816471535 cites W2113623044 @default.
- W1816471535 cites W2115479353 @default.
- W1816471535 cites W2115803553 @default.