Matches in SemOpenAlex for { <https://semopenalex.org/work/W181704679> ?p ?o ?g. }
Showing items 1 to 61 of
61
with 100 items per page.
- W181704679 abstract "The need for an inert freely diffusible indicator for blood flow, which is not dependent on the availability of a cyclotron, has led the authors to study the potential of multicyclic polyethers (cryptands) as ligands for radioactive cations available from generators. The in vivo behavior of the complexes (cryptates) should be dominated by the highly lipophilic surface of the cryptand which surrounds the charged radioactive ion. The authors envision cryptate complexes with short-lived generator-produced isotopes but initiated our studies with longer-lived nuclides, including monovalent Ag-110m, divalent Sr-85, and trivalent Ga-67. Cryptates were formed by addition of the radioactive metal to the cryptands (2.2.2) and (2.2.2)BB, as confirmed by octanol:water partition coefficients. Murine distribution kinetics were similar for both Ag and Sr labeled (2.2.2), but dissimilar from the free ion, giving the authors confidence that the ligand was dominating the biodistribution properties of these complexes. At 1-2 min the cryptate distributions were also similar to blood flow expressed as a percentage of cardiac output. There were two important differences between the labels in vivo; Sr was more stable but Ag was more lipophilic. These results suggest that generator-produced isotopes such as Rb-82 (T1/2 = 75 sec) or Cs-128 (T1/2 = 228more » sec) sequestered inside cryptands may be useful freely diffusible tracers for measuring blood flow by positron emission tomography. A cyclotron would not then be required to produce oxygen-15 water (T1/2 = 122 sec).« less" @default.
- W181704679 created "2016-06-24" @default.
- W181704679 creator A5002814609 @default.
- W181704679 creator A5009269015 @default.
- W181704679 creator A5036317607 @default.
- W181704679 creator A5060554712 @default.
- W181704679 date "1984-01-01" @default.
- W181704679 modified "2023-09-24" @default.
- W181704679 title "Cryptate complexes of generator produced isotopes for measurement of blood flow" @default.
- W181704679 hasPublicationYear "1984" @default.
- W181704679 type Work @default.
- W181704679 sameAs 181704679 @default.
- W181704679 citedByCount "0" @default.
- W181704679 crossrefType "journal-article" @default.
- W181704679 hasAuthorship W181704679A5002814609 @default.
- W181704679 hasAuthorship W181704679A5009269015 @default.
- W181704679 hasAuthorship W181704679A5036317607 @default.
- W181704679 hasAuthorship W181704679A5060554712 @default.
- W181704679 hasConcept C114595235 @default.
- W181704679 hasConcept C121332964 @default.
- W181704679 hasConcept C135788738 @default.
- W181704679 hasConcept C145148216 @default.
- W181704679 hasConcept C164304813 @default.
- W181704679 hasConcept C177322064 @default.
- W181704679 hasConcept C178790620 @default.
- W181704679 hasConcept C179104552 @default.
- W181704679 hasConcept C185592680 @default.
- W181704679 hasConcept C202751555 @default.
- W181704679 hasConcept C2777807558 @default.
- W181704679 hasConcept C552554468 @default.
- W181704679 hasConcept C55493867 @default.
- W181704679 hasConcept C555352317 @default.
- W181704679 hasConcept C62520636 @default.
- W181704679 hasConceptScore W181704679C114595235 @default.
- W181704679 hasConceptScore W181704679C121332964 @default.
- W181704679 hasConceptScore W181704679C135788738 @default.
- W181704679 hasConceptScore W181704679C145148216 @default.
- W181704679 hasConceptScore W181704679C164304813 @default.
- W181704679 hasConceptScore W181704679C177322064 @default.
- W181704679 hasConceptScore W181704679C178790620 @default.
- W181704679 hasConceptScore W181704679C179104552 @default.
- W181704679 hasConceptScore W181704679C185592680 @default.
- W181704679 hasConceptScore W181704679C202751555 @default.
- W181704679 hasConceptScore W181704679C2777807558 @default.
- W181704679 hasConceptScore W181704679C552554468 @default.
- W181704679 hasConceptScore W181704679C55493867 @default.
- W181704679 hasConceptScore W181704679C555352317 @default.
- W181704679 hasConceptScore W181704679C62520636 @default.
- W181704679 hasLocation W1817046791 @default.
- W181704679 hasOpenAccess W181704679 @default.
- W181704679 hasPrimaryLocation W1817046791 @default.
- W181704679 hasRelatedWork W1982045434 @default.
- W181704679 hasRelatedWork W2123555262 @default.
- W181704679 hasRelatedWork W2155913927 @default.
- W181704679 hasRelatedWork W2157928207 @default.
- W181704679 hasRelatedWork W2320603434 @default.
- W181704679 hasRelatedWork W4745080 @default.
- W181704679 isParatext "false" @default.
- W181704679 isRetracted "false" @default.
- W181704679 magId "181704679" @default.
- W181704679 workType "article" @default.