FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1817224593> ?p ?o ?g. }

• W1817224593 endingPage "G172" @default.
• W1817224593 startingPage "G164" @default.
• W1817224593 abstract "Previous evidence suggests that substance P (SP) activates subpopulations of neurons within the dorsal motor nucleus of the vagus (DMV). In this study we aimed at identifying these subpopulations in relation to their gastrointestinal projection organs or vagal branches and characterizing pharmacologically the SP response. Using whole cell patch-clamp recordings from identified gastrointestinal-projecting vagal motoneurons, we found that SP induced an inward current in all neuronal groups except for cecum-projecting cells. The lowest percentage of SP-responding neurons was found in fundus-projecting cells, where SP also had a concentration-response curve that was shifted to the left (P < 0.05). Independently from the projections, the SP response was reduced by sendide and MEN 10,376 and mimicked by a combination of [Sar(9)-Met(O(2))(11)]SP and alpha-neurokinin. SP and alpha-neurokinin also increased the frequency, but not the amplitude, of postsynaptic currents. In conclusion, we demonstrated that SP induces both pre- and postsynaptic effects on DMV neurons via activation of neurokinin NK(1) and NK(2) receptors. The magnitude of the SP response was correlated to the peripheral target organ." @default.
• W1817224593 created "2016-06-24" @default.
• W1817224593 creator A5023369485 @default.
• W1817224593 creator A5051307351 @default.
• W1817224593 date "2001-07-01" @default.
• W1817224593 modified "2023-10-11" @default.
• W1817224593 title "Effects of substance P on identified neurons of the rat dorsal motor nucleus of the vagus" @default.
• W1817224593 cites W149934552 @default.
• W1817224593 cites W1503203015 @default.
• W1817224593 cites W1608342164 @default.
• W1817224593 cites W1846195081 @default.
• W1817224593 cites W1968108088 @default.
• W1817224593 cites W1973137251 @default.
• W1817224593 cites W1974003195 @default.
• W1817224593 cites W1974624853 @default.
• W1817224593 cites W1974782548 @default.
• W1817224593 cites W1977806733 @default.
• W1817224593 cites W1978484342 @default.
• W1817224593 cites W1981374765 @default.
• W1817224593 cites W2001768751 @default.
• W1817224593 cites W2002261021 @default.
• W1817224593 cites W2012825981 @default.
• W1817224593 cites W2015265080 @default.
• W1817224593 cites W2018235445 @default.
• W1817224593 cites W2039363091 @default.
• W1817224593 cites W2039671036 @default.
• W1817224593 cites W2040344827 @default.
• W1817224593 cites W2043487443 @default.
• W1817224593 cites W2044162448 @default.
• W1817224593 cites W2070641078 @default.
• W1817224593 cites W2072226186 @default.
• W1817224593 cites W2075777639 @default.
• W1817224593 cites W2088349914 @default.
• W1817224593 cites W2088434753 @default.
• W1817224593 cites W2092453397 @default.
• W1817224593 cites W2093225726 @default.
• W1817224593 cites W2118827322 @default.
• W1817224593 cites W2120121064 @default.
• W1817224593 cites W2141863160 @default.
• W1817224593 cites W2149525198 @default.
• W1817224593 cites W2263399561 @default.
• W1817224593 doi "https://doi.org/10.1152/ajpgi.2001.281.1.g164" @default.
• W1817224593 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3062486" @default.
• W1817224593 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11408269" @default.
• W1817224593 hasPublicationYear "2001" @default.
• W1817224593 type Work @default.
• W1817224593 sameAs 1817224593 @default.
• W1817224593 citedByCount "22" @default.
• W1817224593 countsByYear W18172245932013 @default.
• W1817224593 countsByYear W18172245932014 @default.
• W1817224593 countsByYear W18172245932017 @default.
• W1817224593 countsByYear W18172245932019 @default.
• W1817224593 countsByYear W18172245932021 @default.
• W1817224593 countsByYear W18172245932022 @default.
• W1817224593 crossrefType "journal-article" @default.
• W1817224593 hasAuthorship W1817224593A5023369485 @default.
• W1817224593 hasAuthorship W1817224593A5051307351 @default.
• W1817224593 hasBestOaLocation W18172245932 @default.
• W1817224593 hasConcept C105702510 @default.
• W1817224593 hasConcept C112592302 @default.
• W1817224593 hasConcept C118303440 @default.
• W1817224593 hasConcept C126322002 @default.
• W1817224593 hasConcept C169760540 @default.
• W1817224593 hasConcept C170493617 @default.
• W1817224593 hasConcept C17077164 @default.
• W1817224593 hasConcept C197341189 @default.
• W1817224593 hasConcept C24998067 @default.
• W1817224593 hasConcept C2776533618 @default.
• W1817224593 hasConcept C2777056410 @default.
• W1817224593 hasConcept C2780723820 @default.
• W1817224593 hasConcept C2781404750 @default.
• W1817224593 hasConcept C2909432713 @default.
• W1817224593 hasConcept C46762472 @default.
• W1817224593 hasConcept C71924100 @default.
• W1817224593 hasConcept C86803240 @default.
• W1817224593 hasConceptScore W1817224593C105702510 @default.
• W1817224593 hasConceptScore W1817224593C112592302 @default.
• W1817224593 hasConceptScore W1817224593C118303440 @default.
• W1817224593 hasConceptScore W1817224593C126322002 @default.
• W1817224593 hasConceptScore W1817224593C169760540 @default.
• W1817224593 hasConceptScore W1817224593C170493617 @default.
• W1817224593 hasConceptScore W1817224593C17077164 @default.
• W1817224593 hasConceptScore W1817224593C197341189 @default.
• W1817224593 hasConceptScore W1817224593C24998067 @default.
• W1817224593 hasConceptScore W1817224593C2776533618 @default.
• W1817224593 hasConceptScore W1817224593C2777056410 @default.
• W1817224593 hasConceptScore W1817224593C2780723820 @default.
• W1817224593 hasConceptScore W1817224593C2781404750 @default.
• W1817224593 hasConceptScore W1817224593C2909432713 @default.
• W1817224593 hasConceptScore W1817224593C46762472 @default.
• W1817224593 hasConceptScore W1817224593C71924100 @default.
• W1817224593 hasConceptScore W1817224593C86803240 @default.
• W1817224593 hasIssue "1" @default.
• W1817224593 hasLocation W18172245931 @default.
• W1817224593 hasLocation W18172245932 @default.
• W1817224593 hasLocation W18172245933 @default.
• W1817224593 hasLocation W18172245934 @default.
• W1817224593 hasOpenAccess W1817224593 @default.

• next