Matches in SemOpenAlex for { <https://semopenalex.org/work/W1817401304> ?p ?o ?g. }
- W1817401304 endingPage "313" @default.
- W1817401304 startingPage "301" @default.
- W1817401304 abstract "Mechanical ventilation is an essential method of patient support, but it may induce lung damage, leading to ventilator-induced lung injury (VILI). VILI is the result of a complex interplay among various mechanical forces that act on lung structures, such as type I and II epithelial cells, endothelial cells, macrophages, peripheral airways, and the extracellular matrix (ECM), during mechanical ventilation. This article discusses ongoing research focusing on mechanisms of VILI in previously healthy lungs, such as in the perioperative period, and the development of new ventilator strategies for surgical patients. Several experimental and clinical studies have been conducted to evaluate the mechanisms of mechanotransduction in each cell type and in the ECM, as well as the role of different ventilator parameters in inducing or preventing VILI. VILI may be attenuated by reducing the tidal volume; however, the use of higher or lower levels of positive end-expiratory pressure (PEEP) and recruitment maneuvers during the perioperative period is a matter of debate. Many questions concerning the mechanisms of VILI in surgical patients remain unanswered. The optimal threshold value of each ventilator parameter to reduce VILI is also unclear. Further experimental and clinical studies are necessary to better evaluate ventilator settings during the perioperative period in different types of surgery." @default.
- W1817401304 created "2016-06-24" @default.
- W1817401304 creator A5014421009 @default.
- W1817401304 creator A5035944991 @default.
- W1817401304 creator A5091455922 @default.
- W1817401304 date "2015-09-01" @default.
- W1817401304 modified "2023-10-16" @default.
- W1817401304 title "Mechanisms of ventilator-induced lung injury in healthy lungs" @default.
- W1817401304 cites W1630706121 @default.
- W1817401304 cites W1764824114 @default.
- W1817401304 cites W1888618913 @default.
- W1817401304 cites W1910618583 @default.
- W1817401304 cites W1913451636 @default.
- W1817401304 cites W1966908481 @default.
- W1817401304 cites W1969307336 @default.
- W1817401304 cites W1973121659 @default.
- W1817401304 cites W1978466130 @default.
- W1817401304 cites W1979158016 @default.
- W1817401304 cites W1979694983 @default.
- W1817401304 cites W1981114950 @default.
- W1817401304 cites W1984461252 @default.
- W1817401304 cites W1987383242 @default.
- W1817401304 cites W1992217737 @default.
- W1817401304 cites W2005060346 @default.
- W1817401304 cites W2009499549 @default.
- W1817401304 cites W2014116796 @default.
- W1817401304 cites W2015163737 @default.
- W1817401304 cites W2019439696 @default.
- W1817401304 cites W2024288745 @default.
- W1817401304 cites W2028536701 @default.
- W1817401304 cites W2029245990 @default.
- W1817401304 cites W2030871870 @default.
- W1817401304 cites W2033864841 @default.
- W1817401304 cites W2035712476 @default.
- W1817401304 cites W2036011073 @default.
- W1817401304 cites W2038798818 @default.
- W1817401304 cites W2042276282 @default.
- W1817401304 cites W2043526762 @default.
- W1817401304 cites W2054703329 @default.
- W1817401304 cites W2057127913 @default.
- W1817401304 cites W2059217150 @default.
- W1817401304 cites W2062716218 @default.
- W1817401304 cites W2063404320 @default.
- W1817401304 cites W2069368135 @default.
- W1817401304 cites W2069708964 @default.
- W1817401304 cites W2076991415 @default.
- W1817401304 cites W2082454963 @default.
- W1817401304 cites W2083670860 @default.
- W1817401304 cites W2084862813 @default.
- W1817401304 cites W2085961403 @default.
- W1817401304 cites W2095052442 @default.
- W1817401304 cites W2096719630 @default.
- W1817401304 cites W2097466236 @default.
- W1817401304 cites W2098748561 @default.
- W1817401304 cites W2099084945 @default.
- W1817401304 cites W2101021628 @default.
- W1817401304 cites W2105910778 @default.
- W1817401304 cites W2105999224 @default.
- W1817401304 cites W2106087880 @default.
- W1817401304 cites W2107194595 @default.
- W1817401304 cites W2108527581 @default.
- W1817401304 cites W2109670147 @default.
- W1817401304 cites W2113960845 @default.
- W1817401304 cites W2114084948 @default.
- W1817401304 cites W2119284420 @default.
- W1817401304 cites W2120164401 @default.
- W1817401304 cites W2122768693 @default.
- W1817401304 cites W2125766343 @default.
- W1817401304 cites W2129270987 @default.
- W1817401304 cites W2129319626 @default.
- W1817401304 cites W2132239682 @default.
- W1817401304 cites W2134952694 @default.
- W1817401304 cites W2135371537 @default.
- W1817401304 cites W2137053070 @default.
- W1817401304 cites W2138045528 @default.
- W1817401304 cites W2142335737 @default.
- W1817401304 cites W2142485527 @default.
- W1817401304 cites W2143604872 @default.
- W1817401304 cites W2145583966 @default.
- W1817401304 cites W2147164306 @default.
- W1817401304 cites W2147628325 @default.
- W1817401304 cites W2151480919 @default.
- W1817401304 cites W2152248433 @default.
- W1817401304 cites W2153134843 @default.
- W1817401304 cites W2154483538 @default.
- W1817401304 cites W2155853288 @default.
- W1817401304 cites W2156291518 @default.
- W1817401304 cites W2160943337 @default.
- W1817401304 cites W2161469273 @default.
- W1817401304 cites W2162002744 @default.
- W1817401304 cites W2162313829 @default.
- W1817401304 cites W2162876978 @default.
- W1817401304 cites W2164811631 @default.
- W1817401304 cites W2164938590 @default.
- W1817401304 cites W2167718580 @default.
- W1817401304 cites W2170236185 @default.
- W1817401304 cites W2171778002 @default.
- W1817401304 cites W2337057834 @default.