FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1817478560> ?p ?o ?g. }

• W1817478560 endingPage "533" @default.
• W1817478560 startingPage "525" @default.
• W1817478560 abstract "Fentanyl, a mu-opioid receptor agonist, produces analgesia while leaving vibrotactile sensation intact. We used positron emission tomography (PET) to study the mechanisms mediating this specific effect in healthy, right-handed human males (ages 18-28 yr). Subjects received either painful cold (n = 11) or painless vibratory (n = 9) stimulation before and after the intravenous injection of fentanyl (1.5 microgram/kg) or placebo (saline). Compared with cool water (29 degrees C), immersion of the hand in ice water (1 degrees C) is painful and produces highly significant increases in regional cerebral blood flow (rCBF) within the contralateral second somatosensory (S2) and insular cortex, bilaterally in the thalamus and cerebellum, and medially in the cerebellar vermis. Responses just below the statistical threshold (3.5 < Z < 4.0) are seen in the contralateral anterior cingulate, ipsilateral insular cortex, and dorsal medial midbrain. The contralateral primary sensory cortex (S1) shows a trend of activation. Except for slight changes in intensity, this pattern is unchanged following a saline placebo injection. Fentanyl reduces the average visual analogue scale ratings of perceived pain intensity (47%) and unpleasantness (50%), reduces pain-related cardioacceleration, and has positive hedonic effects. After fentanyl, but not placebo, all cortical and subcortical responses to noxious cold are greatly reduced. Subtraction analysis [(innocuous water + fentanyl) - (innocuous water + no injection)] shows that fentanyl alone increases rCBF in the anterior cingulate cortex, particularly in the perigenual region. Vibration (compared with mock vibration) evokes highly significant rCBF responses in the contralateral S1 cortex in the baseline (no injection) and placebo conditions; borderline responses (3.5 < Z < 4. 0) are detected also in the contralateral thalamus. Fentanyl has no effect on the perceived intensity or unpleasantness of vibratory stimulation, which continues to activate contralateral S1. Fentanyl alone [(mock vibration + fentanyl) - (mock vibration + no injection)] again produces highly significant activation of the perigenual and mid-anterior cingulate cortex. A specific comparison of volumes of interest, developed from activation peaks in the baseline condition (no injection), shows that fentanyl strongly attenuates both the contralateral thalamic and S1 cortical responses to noxious cold stimulation (P < 0.048 and 0.007, respectively) but fails to affect significantly these responses to vibrotactile stimulation (P > 0.26 and 0.91, respectively). In addition, fentanyl, compared with placebo, produces a unique activation of the mid-anterior cingulate cortex during fentanyl analgesia, suggesting that this region of the cingulate cortex participates actively in mediating opioid analgesia. The results are consistent with a selective, fentanyl-mediated suppression of nociceptive spinothalamic transmission to the forebrain. This effect could be implemented directly at the spinal level, indirectly through cingulate corticofugal pathways, or by a combination of both mechanisms." @default.
• W1817478560 created "2016-06-24" @default.
• W1817478560 creator A5007318813 @default.
• W1817478560 creator A5021406150 @default.
• W1817478560 creator A5032652140 @default.
• W1817478560 creator A5041256825 @default.
• W1817478560 creator A5043756816 @default.
• W1817478560 creator A5069632174 @default.
• W1817478560 date "2000-07-01" @default.
• W1817478560 modified "2023-09-26" @default.
• W1817478560 title "Selective Opiate Modulation of Nociceptive Processing in the Human Brain" @default.
• W1817478560 cites W1591789321 @default.
• W1817478560 cites W1773001224 @default.
• W1817478560 cites W1843502981 @default.
• W1817478560 cites W1968280685 @default.
• W1817478560 cites W1970830073 @default.
• W1817478560 cites W1980854480 @default.
• W1817478560 cites W1981658220 @default.
• W1817478560 cites W1988244181 @default.
• W1817478560 cites W1999108896 @default.
• W1817478560 cites W2000311772 @default.
• W1817478560 cites W2009210592 @default.
• W1817478560 cites W2011890689 @default.
• W1817478560 cites W2029569264 @default.
• W1817478560 cites W2035015555 @default.
• W1817478560 cites W2039859978 @default.
• W1817478560 cites W2048726661 @default.
• W1817478560 cites W2049489255 @default.
• W1817478560 cites W2051691068 @default.
• W1817478560 cites W2052495267 @default.
• W1817478560 cites W2059610821 @default.
• W1817478560 cites W2060012280 @default.
• W1817478560 cites W2070036878 @default.
• W1817478560 cites W2073728822 @default.
• W1817478560 cites W2075740393 @default.
• W1817478560 cites W2085955270 @default.
• W1817478560 cites W2115370667 @default.
• W1817478560 cites W2115741564 @default.
• W1817478560 cites W2121696264 @default.
• W1817478560 cites W2132284897 @default.
• W1817478560 cites W2138512124 @default.
• W1817478560 cites W2141901630 @default.
• W1817478560 cites W2143034408 @default.
• W1817478560 cites W2149688854 @default.
• W1817478560 cites W2319484751 @default.
• W1817478560 cites W2345257971 @default.
• W1817478560 cites W3162552674 @default.
• W1817478560 cites W4238475729 @default.
• W1817478560 doi "https://doi.org/10.1152/jn.2000.84.1.525" @default.
• W1817478560 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10899224" @default.
• W1817478560 hasPublicationYear "2000" @default.
• W1817478560 type Work @default.
• W1817478560 sameAs 1817478560 @default.
• W1817478560 citedByCount "169" @default.
• W1817478560 countsByYear W18174785602012 @default.
• W1817478560 countsByYear W18174785602013 @default.
• W1817478560 countsByYear W18174785602014 @default.
• W1817478560 countsByYear W18174785602015 @default.
• W1817478560 countsByYear W18174785602016 @default.
• W1817478560 countsByYear W18174785602017 @default.
• W1817478560 countsByYear W18174785602018 @default.
• W1817478560 countsByYear W18174785602019 @default.
• W1817478560 countsByYear W18174785602021 @default.
• W1817478560 countsByYear W18174785602022 @default.
• W1817478560 countsByYear W18174785602023 @default.
• W1817478560 crossrefType "journal-article" @default.
• W1817478560 hasAuthorship W1817478560A5007318813 @default.
• W1817478560 hasAuthorship W1817478560A5021406150 @default.
• W1817478560 hasAuthorship W1817478560A5032652140 @default.
• W1817478560 hasAuthorship W1817478560A5041256825 @default.
• W1817478560 hasAuthorship W1817478560A5043756816 @default.
• W1817478560 hasAuthorship W1817478560A5069632174 @default.
• W1817478560 hasConcept C126322002 @default.
• W1817478560 hasConcept C142724271 @default.
• W1817478560 hasConcept C15490471 @default.
• W1817478560 hasConcept C15744967 @default.
• W1817478560 hasConcept C169760540 @default.
• W1817478560 hasConcept C169900460 @default.
• W1817478560 hasConcept C170493617 @default.
• W1817478560 hasConcept C172497186 @default.
• W1817478560 hasConcept C204787440 @default.
• W1817478560 hasConcept C27081682 @default.
• W1817478560 hasConcept C2778402161 @default.
• W1817478560 hasConcept C2778586271 @default.
• W1817478560 hasConcept C2780539906 @default.
• W1817478560 hasConcept C2781072394 @default.
• W1817478560 hasConcept C2781210436 @default.
• W1817478560 hasConcept C42219234 @default.
• W1817478560 hasConcept C529278444 @default.
• W1817478560 hasConcept C71924100 @default.
• W1817478560 hasConceptScore W1817478560C126322002 @default.
• W1817478560 hasConceptScore W1817478560C142724271 @default.
• W1817478560 hasConceptScore W1817478560C15490471 @default.
• W1817478560 hasConceptScore W1817478560C15744967 @default.
• W1817478560 hasConceptScore W1817478560C169760540 @default.
• W1817478560 hasConceptScore W1817478560C169900460 @default.
• W1817478560 hasConceptScore W1817478560C170493617 @default.
• W1817478560 hasConceptScore W1817478560C172497186 @default.

• next