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- W1817756509 abstract "The cytokine profile of OCD: pathophysiological insights Donatella Marazziti, Federico Mucci, Amedeo Lombardi, Valentina Falaschi, Liliana Dell'Osso Dipartimento di Medicina Clinica e Sperimentale, Section of Psychiatry, University of Pisa, Pisa, Italy Abstract: Obsessive-compulsive disorder (OCD) is a psychiatric condition characterized by the presence of obsessions and/or compulsions, which has been commonly associated with alterations of some neurotransmitters systems, in particular, the serotonin and dopamine ones. However, it is now evident that these supposed disturbances cannot explain the development of this disorder, and so other possible mechanisms have been invoked, such as those involving the immune system that is attracting an increasing interest. According to the current literature, immune system alterations are reported in OCD of both children and adults. In children, it has been widely described as a clinical syndrome resulting from infections driven by group A β-hemolytic streptococci and characterized by rheumatic fever, OCD, and neurological symptoms called "pediatric autoimmune neuropsychiatric disorders associated with streptococcus". In adults, available findings are meager and controversial, although intriguing. Such preliminary findings underline the presence of OCD in a number of autoimmune disorders, as well as of alterations of different immune parameters in OCD patients. This paper aims at presenting an exhaustive review of the role of the immune system in the development of OCD, with a major focus on the possible pathophysiological role of cytokines that seems to open novel treatment options. Keywords: OCD, cytokines, immune system, inflammation, PANDAS" @default.
- W1817756509 created "2016-06-24" @default.
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- W1817756509 date "2015-09-01" @default.
- W1817756509 modified "2023-10-17" @default.
- W1817756509 title "The cytokine profile of OCD: pathophysiological insights" @default.
- W1817756509 cites W119082179 @default.
- W1817756509 cites W1514008783 @default.
- W1817756509 cites W1520434148 @default.
- W1817756509 cites W1553210510 @default.
- W1817756509 cites W1578438134 @default.
- W1817756509 cites W161422572 @default.
- W1817756509 cites W1819840072 @default.
- W1817756509 cites W1861053103 @default.
- W1817756509 cites W1900710622 @default.
- W1817756509 cites W1964121512 @default.
- W1817756509 cites W1965666333 @default.
- W1817756509 cites W1965739148 @default.
- W1817756509 cites W1970123539 @default.
- W1817756509 cites W1970477316 @default.
- W1817756509 cites W1972328841 @default.
- W1817756509 cites W1975357271 @default.
- W1817756509 cites W1976582031 @default.
- W1817756509 cites W1976856401 @default.
- W1817756509 cites W1977426012 @default.
- W1817756509 cites W1978589950 @default.
- W1817756509 cites W1980004887 @default.
- W1817756509 cites W1980109413 @default.
- W1817756509 cites W1981658584 @default.
- W1817756509 cites W1981867040 @default.
- W1817756509 cites W1981892938 @default.
- W1817756509 cites W1983891526 @default.
- W1817756509 cites W1984748165 @default.
- W1817756509 cites W1985438873 @default.
- W1817756509 cites W1985855146 @default.
- W1817756509 cites W1986683334 @default.
- W1817756509 cites W1990007881 @default.
- W1817756509 cites W1992539245 @default.
- W1817756509 cites W1992597578 @default.
- W1817756509 cites W1993178195 @default.
- W1817756509 cites W1994200860 @default.
- W1817756509 cites W1997741731 @default.
- W1817756509 cites W1999333586 @default.
- W1817756509 cites W2000349797 @default.
- W1817756509 cites W2001162433 @default.
- W1817756509 cites W2002820793 @default.
- W1817756509 cites W2004218835 @default.
- W1817756509 cites W2004322597 @default.
- W1817756509 cites W2013765217 @default.
- W1817756509 cites W2014111814 @default.
- W1817756509 cites W2017985363 @default.
- W1817756509 cites W2020636839 @default.
- W1817756509 cites W2021274912 @default.
- W1817756509 cites W2021723318 @default.
- W1817756509 cites W2022461628 @default.
- W1817756509 cites W2024418426 @default.
- W1817756509 cites W202591055 @default.
- W1817756509 cites W2030422166 @default.
- W1817756509 cites W2030593831 @default.
- W1817756509 cites W2035708715 @default.
- W1817756509 cites W2036657651 @default.
- W1817756509 cites W2036792358 @default.
- W1817756509 cites W2041060189 @default.
- W1817756509 cites W2041111755 @default.
- W1817756509 cites W2041858687 @default.
- W1817756509 cites W2043884992 @default.
- W1817756509 cites W2043909203 @default.
- W1817756509 cites W2045215812 @default.
- W1817756509 cites W2045544714 @default.
- W1817756509 cites W2046161446 @default.
- W1817756509 cites W2048096554 @default.
- W1817756509 cites W2048431959 @default.
- W1817756509 cites W2049040593 @default.
- W1817756509 cites W2050000178 @default.
- W1817756509 cites W2050039627 @default.
- W1817756509 cites W2050442674 @default.
- W1817756509 cites W2051808553 @default.
- W1817756509 cites W2052139158 @default.
- W1817756509 cites W2053135642 @default.
- W1817756509 cites W2057060667 @default.
- W1817756509 cites W2057784785 @default.
- W1817756509 cites W2060345189 @default.
- W1817756509 cites W2061013031 @default.
- W1817756509 cites W2063217688 @default.
- W1817756509 cites W2064577289 @default.
- W1817756509 cites W2065518321 @default.
- W1817756509 cites W2066206079 @default.
- W1817756509 cites W2074869406 @default.
- W1817756509 cites W2076027411 @default.
- W1817756509 cites W2079384041 @default.
- W1817756509 cites W2079806280 @default.
- W1817756509 cites W2081836849 @default.
- W1817756509 cites W2083935828 @default.
- W1817756509 cites W2084977697 @default.