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• W1817966171 abstract "We used a series of deletion mutations in the untranslated leader region of human immunodeficiency virus type 2 (HIV-2) to seek cis-acting packaging signals. Sequences between the 5' major splice donor and the gag initiation codon, where such signals have been identified in HIV-1, appear to make a measurable but very minor contribution to genomic RNA packaging, and deletions here had little effect on viral replication in vitro. Immediately 5' to the splice donor, two regions were identified which, when deleted, caused a significant replication defect. The most proximal of these to the splice donor demonstrated a phenotype consistent with its being a major cis-acting packaging signal in HIV-2." @default.
• W1817966171 created "2016-06-24" @default.
• W1817966171 creator A5007778580 @default.
• W1817966171 creator A5044246387 @default.
• W1817966171 date "1997-05-01" @default.
• W1817966171 modified "2023-09-25" @default.
• W1817966171 title "Location of cis-acting signals important for RNA encapsidation in the leader sequence of human immunodeficiency virus type 2" @default.
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• W1817966171 doi "https://doi.org/10.1128/jvi.71.5.4133-4137.1997" @default.
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