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• W1818200260 abstract "Summary. Anti-inflammatory effects of O cimum americanum L. essential oil (OEO) were investigated using carrageenan-induced pleurisy in rats, carrageenan-induced rolling and adhesion of leucocytes by technique of intravital microscopy in situ , ear edema induced by croton oil and myeloperoxidase determination in mice. The OEO administered orally at doses of 100, 200 and 400 mg/kg significantly inhibited the exudate pleural volume (p<0.05), without interfere with the number of migrated cells in the carrageenan-induced pleurisy model. While evaluating ear edema induced by croton oil, OEO oral treatment (100, 200 and 400 mg/kg) and OEO topical application (1.0, 2.0 and 4.0 mg/ear) were able to reduce the edema formation (p<0.05). In myeloperoxidase determination, oral treatment  with OEO at doses 100 and 200mg/kg and topical application 1.0, 2.0 mg/ear showed significant inhibition (p<0.05). In the technique of intravital microscopy in situ , OEO orally treated at doses of 100, 200 and 400 mg/kg reduced the leukocyte rolling in 35, 37 and 51%, respectively, whereas, leukocyte adhesion was inhibited by 68% (100 mg/kg) and 43% (200 mg/kg). Thus, our results suggest that the screening with OEO realized in this new study can be useful in the future for the treatment of disease of origin inflammatory. Industrial relevance . The leaves of Ocimum americanun are traditionally used in the treatment of various types of inflammatory diseases. However, there is no scientific data available given supporting. Hence, we conducted this study to evaluate the anti-nflammatory potential of the Ocimum americanun essential oil in different experimental models of acute inflammation. The screening of the biological activity of this essential oil responsible for the anti-inflammatory property may be useful to development of new drug anti-inflammatory, on a commercial scale. Keywords. Ocimum americanum ; leukocyte migration; essential oil; edema" @default.
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• W1818200260 date "2014-05-16" @default.
• W1818200260 modified "2023-10-03" @default.
• W1818200260 title "Evaluation of the potential anti-inflammatory of Ocimum americanum L. essential oil in different experimental models of acute inflammation" @default.
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