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• W1818443590 abstract "Citation Atay S, Gercel-Taylor C, Suttles J, Mor G, Taylor DD. Trophoblast-derived exosomes mediate monocyte recruitment and differentiation. Am J Reprod Immunol 2011; 65: 65–77 Introduction Trophoblast cells have been demonstrated to regulate monocyte migration and differentiation, leading to pro-inflammatory profiles. Because trophoblast cells release exosomes with immunoregulatory properties, trophoblast-derived exosomes are proposed to ‘educate’ monocytes, creating a pro-inflammatory environment. Method of study Exosomes were isolated from conditioned media of Swan71 cells by ultrafiltration and ultracentrifugation. Exosome-induced migration was assessed using a two-chamber system. Cytokine profiles were defined using cytokine arrays, and mRNA levels of affected cytokines were examined by qRT-PCR and ELISA. Results Within 20 min, 8–10% of monocytes took up labeled exosomes isolated from Swan71 cells. Trophoblast-derived exosomes increased monocyte migration in a dose-dependent manner and produced significant increases in production of interleukin (IL)-1β, IL-6, Serpin-E1, granulocyte colony-stimulating factor, granulocyte/monocyte colony-stimulating factor, and tumor necrosis factor-α. Conclusion This study presents the initial demonstration that trophoblast-derived exosomes are capable of recruiting and ‘educating’ monocytes to produce pro-inflammatory cytokine/chemokine profiles in a cell-contact-independent manner." @default.
• W1818443590 created "2016-06-24" @default.
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• W1818443590 date "2010-12-09" @default.
• W1818443590 modified "2023-10-12" @default.
• W1818443590 title "Trophoblast-Derived Exosomes Mediate Monocyte Recruitment and Differentiation" @default.
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• W1818443590 doi "https://doi.org/10.1111/j.1600-0897.2010.00880.x" @default.
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