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• W1818584413 abstract "Abstract Modulation of immune responses may form a powerful approach to treat atherosclerosis. It was shown that clearance of apoptotic cells results in tolerance induction to cleared Ags by dendritic cells (DCs); however, this seems impaired in atherosclerosis because Ag-specific tolerance is lacking. This could result, in part, from decreased emigration of DCs from atherosclerotic lesions because of the high-cholesterol environment. Nonetheless, local induction of anti-inflammatory responses by apoptotic cell clearance seems to dampen atherosclerosis, because inhibition of apoptotic cell clearance worsens atherosclerosis. In this study, we assessed whether i.v. administration of oxLDL-induced apoptotic DCs (apopox-DCs) and, as a control, unpulsed apoptotic DCs could modulate atherosclerosis by inducing tolerance. Adoptive transfer of apopox-DCs into low-density lipoprotein receptor knockout mice either before or during feeding of a Western-type diet resulted in increased numbers of CD103+ tolerogenic splenic DCs, with a concomitant increase in regulatory T cells. Interestingly, both types of apoptotic DCs induced an immediate 40% decrease in Ly-6Chi monocyte numbers and a 50% decrease in circulating CCL2 levels, but only apopox-DC treatment resulted in long-term effects on monocytes and CCL2 levels. Although initial lesion development was reduced by 40% in both treatment groups, only apopox-DC treatment prevented lesion progression by 28%. Moreover, progressed lesions of apopox-DC–treated mice showed a robust 45% increase in collagen content, indicating an enhanced stability of lesions. Our findings clearly show that apoptotic DC treatment significantly decreases lesion development, but only apopox-DCs can positively modulate lesion progression and stability. These findings may translate into a safe treatment for patients with established cardiovascular diseases using patient-derived apopox-DCs." @default.
• W1818584413 created "2016-06-24" @default.
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• W1818584413 date "2015-03-01" @default.
• W1818584413 modified "2023-09-27" @default.
• W1818584413 title "Oxidized Low-Density Lipoprotein–Induced Apoptotic Dendritic Cells as a Novel Therapy for Atherosclerosis" @default.
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• W1818584413 doi "https://doi.org/10.4049/jimmunol.1401843" @default.
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• W1818584413 hasPublicationYear "2015" @default.
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