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- W1818586020 abstract "Hemos valorado en 68 niños (edad media: 9 años) el efecto del tratamiento prolongado (media: 255 ± 117 días) con budesonida inhalada en aerosol y cámara espaciadora a dosis variables (media: 1,42 mg/1,73 m2/día) sobre la función suprarrenal, mediante el test de ACTH (250 pg i.v.) ampliado a aldosterona, con determinaciones basales de ACTH, actividad de renina plasmática, sodio y potasio. Los valores basales medios fueron: cortisol 313 ± 138 nmol/1 y aldosterona 0,25 ± 0,20 nmol/1. En 4 casos el cortisol basal fue inferior a 130 nmol/1. La respuesta obtenida tras administrar ACTH fue normal para la aldosterona y para el cortisol fue parcial en 2 casos. Concluimos que: a) la determinación de aldosterona no aporta datos significativos en el test de ACTH y que b) en el 4,4% de los casos se observa alguna disfunción suprarrenal tras inhalación prolongada de budesonida en niños. We evaluated the effect of long-term treatment (255 ± days) with budesonide aerosol inhaled from a spacer device by 68 children (mean age 9 yr) receiving variable doses (mean: 1.42 mg/1.73 m2/day). The effect on suprarenal function was assessed by ACTH test including aldosterone activity, basal ACTH levels and blood renin, sodium and potassium levels. Basal values were cortisol 313 ± 138 nmol/L and aldosterone 0.25 ± nmol/L. Basal cortisol was under 130 nmol/1 in 4 cases. The response to ACTH injection was normal for aldosterone and partial for cortisol in 2 cases. We conclude that a) measurement of aldosterone does not add significant information to the ACTH test and b) suprarenal dysfunction after prolonged inhalation of budesonide by children is found in 4.4% of patients." @default.
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- W1818586020 date "1993-11-01" @default.
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- W1818586020 title "Inhalación prolongada de budesonida en niños y respuesta suprarrenal" @default.
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- W1818586020 doi "https://doi.org/10.1016/s0300-2896(15)31163-7" @default.
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