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- W1818684172 endingPage "657" @default.
- W1818684172 startingPage "647" @default.
- W1818684172 abstract "Both chronic and acute dermal wounds are susceptible to infection due to sterile loss of the innate barrier function of the skin and dermal appendages, facilitating the development of microbial communities, referred to as biofilms, within the wound environment. Microbial biofilms are implicated in both the infection of wounds and failure of those wounds to heal. The aim of this review is to provide a summary of published papers detailing biofilms in wounds, the effect they have on infection and wound healing, and detailing methods employed for their detection. The studies highlighted within this paper provide evidence that biofilms reside within the chronic wound and represent an important mechanism underlying the observed, delayed healing and infection. The reasons for this include both protease activity and immunological suppression. Furthermore, a lack of responsiveness to an array of antimicrobial agents has been due to the biofilms' ability to inherently resist antimicrobial agents. It is imperative that effective strategies are developed, tested prospectively, and employed in chronic wounds to support the healing process and to reduce infection rates. It is increasingly apparent that adoption of a biofilm-based management approach to wound care, utilizing the antibiofilm tool box of therapies, to kill and prevent reattachment of microorganisms in the biofilm is producing the most positive clinical outcomes and prevention of infection." @default.
- W1818684172 created "2016-06-24" @default.
- W1818684172 creator A5010362194 @default.
- W1818684172 creator A5014792305 @default.
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- W1818684172 creator A5026562442 @default.
- W1818684172 creator A5041346773 @default.
- W1818684172 creator A5061005935 @default.
- W1818684172 date "2012-09-01" @default.
- W1818684172 modified "2023-10-16" @default.
- W1818684172 title "A review of the scientific evidence for biofilms in wounds" @default.
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