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- W181878229 startingPage "1859" @default.
- W181878229 abstract "Anterior cruciate ligament (ACL) rupture is a common ligamentous injury often necessitating surgery. Current surgical treatment options include ligament reconstruction with autograft or allograft, which have their inherent limitations. Thus, there is interest in a tissue-engineered substitute for use in ACL regeneration. However, there have been relatively few in vivo studies to date. In this study, an athymic rat model of ACL reconstruction was used to evaluate electrospun polycaprolactone (PCL) grafts, with and without the addition of basic fibroblast growth factor (bFGF) and human foreskin fibroblasts. We examined the regenerative potential of tissue-engineered ACL grafts using histology, immunohistochemistry, and mechanical testing up to 16 weeks postoperatively. Histology showed infiltration of the grafts with cells, and immunohistochemistry demonstrated aligned collagen deposition with minimal inflammatory reaction. Mechanical testing of the grafts demonstrated significantly higher mechanical properties than immediately postimplantation. Acellular grafts loaded with bFGF achieved 58.8% of the stiffness and 40.7% of the peak load of healthy native ACL. Grafts without bFGF achieved 31.3% of the stiffness and 28.2% of the peak load of healthy native ACL. In this in vivo rodent model study for ACL reconstruction, the histological and mechanical evaluation demonstrated excellent healing and regenerative potential of our electrospun PCL ligament graft." @default.
- W181878229 created "2016-06-24" @default.
- W181878229 creator A5011310825 @default.
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- W181878229 date "2015-06-01" @default.
- W181878229 modified "2023-09-27" @default.
- W181878229 title "Evaluation of Polycaprolactone Scaffold with Basic Fibroblast Growth Factor and Fibroblasts in an Athymic Rat Model for Anterior Cruciate Ligament Reconstruction" @default.
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- W181878229 cites W1973099482 @default.
- W181878229 cites W1977029663 @default.
- W181878229 cites W1983565921 @default.
- W181878229 cites W1993080116 @default.
- W181878229 cites W1996315539 @default.
- W181878229 cites W2005212428 @default.
- W181878229 cites W2006095611 @default.
- W181878229 cites W2009900197 @default.
- W181878229 cites W2010568015 @default.
- W181878229 cites W2015585798 @default.
- W181878229 cites W2017147821 @default.
- W181878229 cites W2017623865 @default.
- W181878229 cites W2018061385 @default.
- W181878229 cites W2021631298 @default.
- W181878229 cites W2022909629 @default.
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- W181878229 cites W2037206705 @default.
- W181878229 cites W2040681734 @default.
- W181878229 cites W2041016801 @default.
- W181878229 cites W2048149237 @default.
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- W181878229 cites W2062304147 @default.
- W181878229 cites W2064146644 @default.
- W181878229 cites W2075760835 @default.
- W181878229 cites W2078321910 @default.
- W181878229 cites W2086483409 @default.
- W181878229 cites W2086992952 @default.
- W181878229 cites W2089921240 @default.
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- W181878229 cites W2164473845 @default.
- W181878229 cites W2164777277 @default.
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- W181878229 cites W2167272466 @default.
- W181878229 cites W2168413755 @default.
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- W181878229 doi "https://doi.org/10.1089/ten.tea.2014.0366" @default.
- W181878229 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4449721" @default.
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- W181878229 hasPublicationYear "2015" @default.
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