Matches in SemOpenAlex for { <https://semopenalex.org/work/W181906651> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W181906651 abstract "Multiple endocrine neoplasia type 1 (MEN1) and type 2 (MEN2) are autosomal dominant inherited multiglandular diseases with familial and individual age-related penetrance and variable expression. The most frequent endocrine features of MEN1 are parathyroid involvement (> 95%), duodeno-pancreatic endocrine tissue involvement (80%), pituitary adenoma (30%), and adrenal cortex tumors (25%), with no clear syndromic variants. Identification of the germline MEN1 mutation confirms the diagnosis, but there is no phenotype-genotype correlation. All patients with MEN2 have medullary thyroid carcinoma (MTC). The most distinctive MEN2 variants are MEN2A (MTC+pheochromocytoma+hyperparathyroidism), MEN2B (MTC+pheo), and isolated familial MTC (FMTC). The prognosis of MEN2 is linked to the progression of MTC, which depends mainly on the stage at diagnosis and the quality of initial surgical treatment. This emphasizes the need for early diagnosis and management. The specific RET codon mutation correlates with the MEN2 syndromic variant and with the age of onset and aggressiveness of MTC. Consequently, RET mutational status should guide major management decisions, such as whether and when to perform thyroidectomy." @default.
- W181906651 created "2016-06-24" @default.
- W181906651 creator A5051447608 @default.
- W181906651 creator A5065743137 @default.
- W181906651 creator A5082610705 @default.
- W181906651 date "2010-01-01" @default.
- W181906651 modified "2023-10-05" @default.
- W181906651 title "Néoplasies endocriniennes multiples, aspects cliniques" @default.
- W181906651 doi "https://doi.org/10.1016/s0001-4079(19)32362-3" @default.
- W181906651 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20669560" @default.
- W181906651 hasPublicationYear "2010" @default.
- W181906651 type Work @default.
- W181906651 sameAs 181906651 @default.
- W181906651 citedByCount "3" @default.
- W181906651 countsByYear W1819066512012 @default.
- W181906651 countsByYear W1819066512013 @default.
- W181906651 crossrefType "journal-article" @default.
- W181906651 hasAuthorship W181906651A5051447608 @default.
- W181906651 hasAuthorship W181906651A5065743137 @default.
- W181906651 hasAuthorship W181906651A5082610705 @default.
- W181906651 hasConcept C104317684 @default.
- W181906651 hasConcept C126322002 @default.
- W181906651 hasConcept C127716648 @default.
- W181906651 hasConcept C13514818 @default.
- W181906651 hasConcept C195121873 @default.
- W181906651 hasConcept C200544954 @default.
- W181906651 hasConcept C2775945674 @default.
- W181906651 hasConcept C2776512331 @default.
- W181906651 hasConcept C2777074255 @default.
- W181906651 hasConcept C2779053571 @default.
- W181906651 hasConcept C2779469564 @default.
- W181906651 hasConcept C2779512018 @default.
- W181906651 hasConcept C2780103800 @default.
- W181906651 hasConcept C46699223 @default.
- W181906651 hasConcept C501734568 @default.
- W181906651 hasConcept C526584372 @default.
- W181906651 hasConcept C54355233 @default.
- W181906651 hasConcept C71315377 @default.
- W181906651 hasConcept C71924100 @default.
- W181906651 hasConcept C86803240 @default.
- W181906651 hasConceptScore W181906651C104317684 @default.
- W181906651 hasConceptScore W181906651C126322002 @default.
- W181906651 hasConceptScore W181906651C127716648 @default.
- W181906651 hasConceptScore W181906651C13514818 @default.
- W181906651 hasConceptScore W181906651C195121873 @default.
- W181906651 hasConceptScore W181906651C200544954 @default.
- W181906651 hasConceptScore W181906651C2775945674 @default.
- W181906651 hasConceptScore W181906651C2776512331 @default.
- W181906651 hasConceptScore W181906651C2777074255 @default.
- W181906651 hasConceptScore W181906651C2779053571 @default.
- W181906651 hasConceptScore W181906651C2779469564 @default.
- W181906651 hasConceptScore W181906651C2779512018 @default.
- W181906651 hasConceptScore W181906651C2780103800 @default.
- W181906651 hasConceptScore W181906651C46699223 @default.
- W181906651 hasConceptScore W181906651C501734568 @default.
- W181906651 hasConceptScore W181906651C526584372 @default.
- W181906651 hasConceptScore W181906651C54355233 @default.
- W181906651 hasConceptScore W181906651C71315377 @default.
- W181906651 hasConceptScore W181906651C71924100 @default.
- W181906651 hasConceptScore W181906651C86803240 @default.
- W181906651 hasLocation W1819066511 @default.
- W181906651 hasLocation W1819066512 @default.
- W181906651 hasOpenAccess W181906651 @default.
- W181906651 hasPrimaryLocation W1819066511 @default.
- W181906651 hasRelatedWork W1589731692 @default.
- W181906651 hasRelatedWork W1972712781 @default.
- W181906651 hasRelatedWork W1990175352 @default.
- W181906651 hasRelatedWork W2008375816 @default.
- W181906651 hasRelatedWork W2011280455 @default.
- W181906651 hasRelatedWork W2034188179 @default.
- W181906651 hasRelatedWork W2036874909 @default.
- W181906651 hasRelatedWork W2053239491 @default.
- W181906651 hasRelatedWork W2054759253 @default.
- W181906651 hasRelatedWork W2057921657 @default.
- W181906651 hasRelatedWork W2072317261 @default.
- W181906651 hasRelatedWork W2079233190 @default.
- W181906651 hasRelatedWork W2112509035 @default.
- W181906651 hasRelatedWork W2127061439 @default.
- W181906651 hasRelatedWork W2134063191 @default.
- W181906651 hasRelatedWork W2153693463 @default.
- W181906651 hasRelatedWork W2286472999 @default.
- W181906651 hasRelatedWork W2341242206 @default.
- W181906651 hasRelatedWork W2404534533 @default.
- W181906651 hasRelatedWork W2416323438 @default.
- W181906651 isParatext "false" @default.
- W181906651 isRetracted "false" @default.
- W181906651 magId "181906651" @default.
- W181906651 workType "article" @default.