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- W1819118049 abstract "INTRODUCTION: Improvements in static lung mechanics and hyperinflation are important therapeutic goals in COPD. AIMS: To investigate the effects of aclidinium on static lung function and hyperinflation in patients with COPD. METHODS: This double-blind, randomized, crossover study compared aclidinium bromide 400 µg BID (metered dose; equivalent to aclidinium 322 µg BID delivered dose) with placebo, each for 3 weeks, in 112 patients with moderate to severe COPD (FEV 1 1.50 L, 56.7% pred). Efficacy variables included: change from baseline in trough inspiratory capacity (IC), FEV 1 and IC/total lung capacity (TLC); trough and 2-hour post-dose functional residual capacity (FRC), residual volume (RV), and specific airway conductance (sGaw); and 2-hour post-dose TLC. RESULTS: see table. CONCLUSIONS: Aclidinium significantly improved static lung hyperinflation in COPD patients." @default.
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- W1819118049 date "2013-09-01" @default.
- W1819118049 modified "2023-09-27" @default.
- W1819118049 title "Effect of aclidinium bromide on static lung function and hyperinflation in patients with moderate to severe COPD" @default.
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