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- W1819249925 endingPage "15" @default.
- W1819249925 startingPage "1" @default.
- W1819249925 abstract "Polymorphonuclear neutrophils (PMNs) are key innate immune cells that represent the first line of defence against infection. They are the first leukocytes to migrate from the blood to injured or infected sites. This process involves molecular mechanisms that coordinate cell polarization, delivery of receptors, and activation of integrins at the leading edge of migrating PMNs. These phagocytes actively engulf microorganisms or form neutrophil extracellular traps (NETs) to trap and kill pathogens with bactericidal compounds. Association of the NADPH oxidase complex at the phagosomal membrane for production of reactive oxygen species (ROS) and delivery of proteolytic enzymes into the phagosome initiate pathogen killing and removal. G protein-dependent signalling pathways tightly control PMN functions. In this review, we will focus on the small monomeric GTPases of the Arf family and their guanine exchange factors (GEFs) and GTPase activating proteins (GAPs) as components of signalling cascades regulating PMN responses. GEFs and GAPs are multidomain proteins that control cellular events in time and space through interaction with other proteins and lipids inside the cells. The number of Arf GAPs identified in PMNs is expanding, and dissecting their functions will provide important insights into the role of these proteins in PMN physiology." @default.
- W1819249925 created "2016-06-24" @default.
- W1819249925 creator A5030871124 @default.
- W1819249925 creator A5042032791 @default.
- W1819249925 creator A5051717671 @default.
- W1819249925 creator A5063674894 @default.
- W1819249925 creator A5085251031 @default.
- W1819249925 date "2015-01-01" @default.
- W1819249925 modified "2023-09-24" @default.
- W1819249925 title "Regulators and Effectors of Arf GTPases in Neutrophils" @default.
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