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• W1819324525 endingPage "C281" @default.
• W1819324525 startingPage "C271" @default.
• W1819324525 abstract "Blood vessels are subjected to numerous biomechanical forces that work harmoniously but, when unbalanced because of vascular smooth muscle cell (vSMC) dysfunction, can trigger a wide range of ailments such as cerebrovascular, peripheral artery, and coronary artery diseases. Human pluripotent stem cells (hPSCs) serve as useful therapeutic tools that may help provide insight on the effect that such biomechanical stimuli have on vSMC function and differentiation. In this study, we aimed to examine the effect of biomechanical strain on vSMCs derived from hPSCs. The effects of two types of tensile strain on hPSC-vSMC derivatives at different stages of differentiation were examined. The derivatives included smooth muscle-like cells (SMLCs), mature SMLCs, and contractile vSMCs. All vSMC derivatives aligned perpendicularly to the direction of cyclic uniaxial strain. Serum deprivation and short-term uniaxial strain had a synergistic effect in enhancing collagen type I, fibronectin, and elastin gene expression. Furthermore, long-term uniaxial strain deterred collagen type III gene expression, whereas long-term circumferential strain upregulated both collagen type III and elastin gene expression. Finally, long-term uniaxial strain downregulated extracellular matrix (ECM) expression in more mature vSMC derivatives while upregulating elastin in less mature vSMC derivatives. Overall, our findings suggest that in vitro application of both cyclic uniaxial and circumferential tensile strain on hPSC-vSMC derivatives induces cell alignment and affects ECM gene expression. Therefore, mechanical stimulation of hPSC-vSMC derivatives using tensile strain may be important in modulating the phenotype and thus the function of vSMCs in tissue-engineered vessels." @default.
• W1819324525 created "2016-06-24" @default.
• W1819324525 creator A5019329595 @default.
• W1819324525 creator A5073874296 @default.
• W1819324525 creator A5084788358 @default.
• W1819324525 date "2015-08-15" @default.
• W1819324525 modified "2023-10-18" @default.
• W1819324525 title "Biomechanical strain induces elastin and collagen production in human pluripotent stem cell-derived vascular smooth muscle cells" @default.
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• W1819324525 doi "https://doi.org/10.1152/ajpcell.00366.2014" @default.
• W1819324525 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4537934" @default.
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