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• W1819528055 abstract "Patients with erythrodermic disease are a diagnostic challenge regarding the clinical and histological differential diagnosis. To evaluate histopathological and immunohistochemical diagnostic markers for Sézary syndrome. Ninety‐seven erythrodermic cases [Sézary syndrome (SS), n =57; erythrodermic inflammatory dermatoses (EIDs), n =40] were collected by the EORTC Cutaneous Lymphoma Task Force histopathology group. Evaluation criteria were (i) epidermal and dermal changes; (ii) morphology of the infiltrate; (iii) immunohistochemical analysis of marker loss (CD2, CD3, CD4, CD5 and CD7); (iv) bystander infiltrate by staining for CD8, FOXP3 and CD25; and (v) expression of Ki‐67, CD30, PD‐1 and MUM‐1. The workshop panel made a correct diagnosis of SS in 51% of cases (cutaneous T‐cell lymphoma 81%) and of EID in 80% without clinical or laboratory data. Histology revealed a significantly increased degree of epidermotropism (P <0·001) and more intraepidermal atypical lymphocytes (P =0·0014) in SS biopsies compared with EID. Pautrier microabscesses were seen only in SS (23%) and not in EID (P =0·0012). SS showed significantly more dermal cerebriform and blastic lymphocytes than EID. Immunohistochemistry revealed a significant loss of CD7 expression (< 50%) in 33 of 51 (65%) cases of SS compared with two of 35 (6%) EID (P <0·001). The lymphocytic infiltrate in SS skin samples was found significantly to express PD‐1 (P =0·0053), MUM‐1 (P =0·0017) and Ki‐67 (P <0·001), and showed less infiltration of CD8+ lymphocytes (P <0·001). A multivariate analysis identified CD7 loss, increased numbers of small cerebriform lymphocytes, low numbers of CD8+ lymphocytes and increased proliferation (Ki‐67+ lymphocytes) as the strongest indicators for the diagnosis of SS. A number of different histological and immunophenotypical criteria are required to differentiate between SS and EIDs." @default.
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• W1819528055 date "2015-06-23" @default.
• W1819528055 modified "2023-10-10" @default.
• W1819528055 title "Histopathological and immunophenotypical criteria for the diagnosis of Sézary syndrome in differentiation from other erythrodermic skin diseases: a European Organisation for Research and Treatment of Cancer (EORTC) Cutaneous Lymphoma Task Force Study of 9" @default.
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• W1819528055 doi "https://doi.org/10.1111/bjd.13832" @default.
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